pre·al·bu·min

(prē'al-byū'min),

1. A protein component of plasma having a molecular weight of about 55,000 and containing 1.3% carbohydrate; estimated plasma concentration is 0.3 g per 100 mL; abnormal levels of prealbumin are found in cases of familial amyloidosis. Synonym(s): transthyretin

2. The protein-containing zone observed in zone electrophoresis of serum that migrates more rapidly than serum albumin.

Farlex Partner Medical Dictionary © Farlex 2012

transthyretin

Prealbumin A 55 kD homotetrameric protein that binds thyroxine and retinol; transthyretin is ↓ in malnutrition and in acute and chronic inflammation, and thus is considered a 'negative acute phase protein', which may be defective in AD amyloidosis. Cf Proalbumin.

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References in periodicals archive

A new diagnostic procedure to detect unknown transthyretin (TTR) mutations in familial amyloidotic polyneuropathy (FAP).

Detection of genetic variants of transthyretin by liquid chromatography-dual electrospray ionization Fourier-transform ion-cyclotron-resonance mass spectrometry

Pfizer's ATTR-ACT study was designed to evaluate clinically meaningful results for the use of the product as a treatment for patients with transthyretin cardiomyopathy, a rare, fatal, and underdiagnosed condition associated with progressive heart failure.

Pfizer's phase three transthyretin cardiomyopathy drug study meets primary endpoint

Electrically neutral microheterogeneity of human plasma transthyretin (prealbumin) detected by isoelectric focusing in urea gradients.

Identification of transthyretin variants by sequential proteomic and genomic analysis

Transthyretin and familial amyloidotic polyneuropathy.

Rapid method to characterize mutations in transthyretin in cerebrospinal fluid from familial amyloidotic polyneuropathy patients by use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

To confirm that the false increase in transthyretin was the result of human antibodies against rabbit immunoglobulins, various classes of immunoglobulin were removed from the serum samples by affinity chromatography.

Falsely increased values for rabbit immunoglobulin-based nephelometric immunoassays attributable to human anti-rabbit antibodies

Long-Term Efficacy and Safety of Inotersen for Hereditary Transthyretin Amyloidosis: NEURO-TTR Open-Label Extension 2-Year by Dr.

Akcea and Ionis to Present New Data for TEGSEDI and AKCEA-TTR-LRx at Two Upcoming Medical Meetings

Intravitreal administration of a conjugated siRNA targeting mouse transthyretin demonstrated a dose-dependent and sustained knockdown of TTR, with maximal (greater than 95%) suppression achieved at doses as low as 15 micrograms per eye and lasting up to Day 135 post a single injection.

Alnylam Touts Progress with RNAi Therapeutics Platform, Including Oral Route of Administration and CNS and Ocular Delivery

The SMC has also accepted patisiran (Onpattro) for the treatment of hereditary transthyretin (hATTR) amyloidosis, a very rare progressive genetic disease in which abnormal proteins build up in tissues around the body including the nerves and the heart.

New asthma jab and 'gene-silencing' drug approved in Scotland; Healthcare: Five new medicines accepted for use on the NHS

The United States Food and Drug Administration (FDA) has approved United States-based Pfizer's Vyndaqel (tafamidis meglumine) and Vyndamax (tafamidis) intended to treat patients with transthyretin amyloid cardiomyopathy, it was reported yesterday.

US FDA approves Pfizer's Vyndaqel and Vyndamax

18, 2018 (HealthDay News) -- In patients with transthyretin amyloid cardiomyopathy, treatment with tafamidis reduces all-cause mortality and cardiovascular-related hospitalizations versus placebo, according to a study published in the Sept.

Tafamidis Treats Transthyretin Amyloid Cardiomyopathy; Reduces all-cause mortality, cardiovascular-related hospitalizations compared with placebo

The 3D liver tissue can be maintained in culture for more than a month, with stable albumin, transthyretin, alpha-1 antitrypsin, and metabolic P450 (CYP3A4, CYP1A2) enzyme protein expression levels that are typically found in mature human liver tissue.

Company Develops 3D liver Structures From Stem Cells