In the experiments outlined below we utilize multiparameter phosphoflow cytometry to simultaneously quantify the activity of several different elements of the BCR
signal transduction pathway on a single cell basis.
The pathway builder portion of Protein Lounge allows users to create their own
signal transduction pathways.
And the regulation of glucose metabolism, hormonal regulation and sugar signal are directly related to
signal transduction (Mathieu et al., 2009; Kleinow et al., 2009).
Protein kinase C (PKC)
signal transduction system involved in larval metamorphosis of the barnacle, Balanus amphitrite.
Since the establishment of the CoBRE in
Signal Transduction, WVU faculty members have published approximately 300 scientific journal articles.
These proprietary lipid mediators, termed "
Signal Transduction Modulators" or STMs, have significant pharmaceutical potential for treating regulatory dysfunctions underlying Alzheimer's, Parkinson's, Rosacea, Psoriasis and other diseases.
The gathering, which was organized by the American Association for Cancer Research (AACR) under the title "From the Laboratory to the Clinic", provided an overview of the most cutting-edge cancer research in various fields, including the tumor microenvironment, microRNAs,
signal transduction, and novel therapeutic development.
type II receptor to inhibit the
signal transduction of human TGF-.beta.
Koretzky, MD, PhD, professor of pathology and laboratory medicine and director of the
Signal Transduction Program at Penn's Abramson Family Cancer Research Institute, describes one way in which T cells may develop tolerance to host cells and proteins.
"Bio-Plex phosphoprotein assays built with CST antibody content provide the means for rigorous parallel analysis of
signal transduction pathways," said CST Director of Business Development Christopher Bunder.
TNF-[alpha]-associated
signal transduction has been well characterized.