mRNA

Abbreviation for messenger RNA. See entries under ribonucleic acid

Farlex Partner Medical Dictionary © Farlex 2012

mRNA

abbr.

messenger RNA

An RNA (ribonucleic acid) molecule which has coding regions and translation signals derived from a gene, carries the reverse template message from DNA, and is required for protein synthesis. mRNA is a nucleic acid intermediate that specifies the amino acid sequence of a polypeptide during translation. Under most circumstances, and in accordance with the so-called central dogma of biology, the message flows from DNA to RNA, which is then translated into protein. DNA is wrapped around proteins (histones in chromatin); the DNA then unwinds, allowing transcription by one of the three RNA polymerases, forming a primary (nuclear) RNA transcript that is then processed to remove the intervening RNA sequences (introns), yielding a mature mRNA molecule. The mature mRNA then passes through nuclear pores into the cytoplasm, where translation into proteins occurs. When a particular mRNA is no longer needed, it is degraded by ribonucleases.

mRNA

Abbreviation for messenger RNA.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

mRNA

see MESSENGER RNA.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive

According to Tables 2 and 3, for the muscle, pancreatic secretion pathway (bta04972) and biological process (BP) term of anterior/posterior pattern specification (BP_GO:0009952) are uniquely found for the mRNA only pipeline.

Multi-tissue observation of the long non-coding RNA effects on sexually biased gene expression in cattle

Because mRNA can be easily broken down in the body, it needs to transported within some kind of protective carrier.

Lung Disease Treatment: Breathe in mRNA

A 7-methyl-guanosine at their 5' ends (5' cap) is another important structure for the expression and the stability of mRNA in cell cytoplasm when mRNA leaves the nucleus.

Enhancing Stability of Destabilized Green Fluorescent Protein Using Chimeric mRNA Containing Human Beta-Globin 5' and 3' Untranslated Regions

51) Although the activation of TLR signaling pathways is normal, the decay of Il-6 mRNA is impaired in [Regnase-1.sup.-/-] macrophages.

Post-transcriptional regulation of immune responses by RNA binding proteins

AATD Hepatocytes were transfected with 4ul of Lipofectamine[R] 2000 (Thermo Fisher Scientific, Inc., Waltham, MA) per 2.5ug mRNA, in 3 independent experiments with 3 biological replicates per experiment.

SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency

It profiles existing vaccines based on mRNA and therapeutics.

New Immunotherapy Report Package by La Merie Publishing Now Available at MarketPublishers.com

Results: SIRT3 mRNA expression was higher in the RA group than in the healthy control group (4.64 fold, p<0.001), whereas SIRT2 mRNA expression was relatively lower in the RA group than in the healthy control group (0.55 fold, p=0.109).

Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis

Upregulation of the mRNA of catalase, an extensively investigated antioxidant, was confirmed by real-time RT-PCR and found to be 1.5 times higher in TM cells treated with Y-27632 compared to the control TM cells (P = 0.032; Figure 1(a)).

Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells

The team knew that mRNA was shipped in a controlled fashion to the endfeet, rather than merely diffusing, but they didn't know which other molecules might control these steps.

Visualization of mechanisms driving formation of neurons

The underlying explanation for improved specificity is detection of mRNA encoding E6 and E7 oncogenic proteins indicating lesion progression to invasive cancer.

mRNA-based hrHPV assay in cotesting for cervical cancer screening