CASC3

A gene on chromosome 17q11-q21.3 that encodes a widely expressed protein which is a core component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC marks the position of the exon–exon junction in the mature mRNA and thereby influences downstream processes of gene expression, including mRNA splicing, nuclear mRNA export, subcellular mRNA localisation, translation efficiency and nonsense-mediated mRNA decay. It interacts with EIF4A3, MAGOH, NXF1 and RBM8A, as well as with STAU in an RNA-dependent fashion.

Molecular pathology
CASC3 is overexpressed in the breast and in gastric cancers.

References in periodicals archive

CASC3 (cancer susceptibility candidate gene 3) was used as a reference gene to normalize the expression of target gene samples in both monolayer and spheroids.

Successful Low-Cost Scaffold-Free Cartilage Tissue Engineering Using Human Cartilage Progenitor Cell Spheroids Formed by Micromolded Nonadhesive Hydrogel

We also tested 5 housekeeping genes [LMNB1, lamin B1; EIF1AX, eukaryotic translation initiation factor 1A, X-linked; CASC3 (also known as MLN51), cancer susceptibility candidate 3; PPIA; and PGK1, phosphoglycerate kinase 1] as endogenous controls (data not shown).

[5] Human genes: LPL, lipoprotein lipase; ZAP70, zeta-chain (ICR) associated protein kinase 70 kDa; PPIA, peptidylprolyl isomerase A (cyclophilin A); LMNB1, lamin B1; EIF1AX, eukaryotic translation initiation factor 1A, X-linked; CASC3, cancer susceptibility candidate 3; IGHV, immunoglobulin variable heavy chain region; PGKI, phosphoglycerate kinase 1; CD38, CD38 molecule.

Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia

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