leu·ko·tri·enes (LT),

(lū'kō-trī'ēnz),

Products of eicosanoid metabolism (usually, arachidonate) with several physiologic roles, such as mediation of inflammation and participation in allergic reactions; leukotrienes differ from the related prostaglandins and thromboxanes in that they do not have a central ring; so named because they were discovered in association with leukocytes and were initially determined to possess three conjugated double bonds; letters A-F identify the first six metabolites isolated, with subscript numbers to indicate the number of double bonds (for example, leukotriene C₄).

Farlex Partner Medical Dictionary © Farlex 2012

leu·ko·tri·enes

(LT) (lū'kō-trī'ēnz)

Products of eicosanoid metabolism with physiologic roles in inflammation and allergic reactions.
Synonym(s): leucotriene.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

leukotrienes

Powerful chemical agents released by MAST CELLS, basophil cells and MACROPHAGES and involved in many allergic and other immunological reactions. Leukotrienes are derived from ARACHIDONIC ACID and cause CHEMOTAXIS and increase the leakiness of small blood vessels. In asthma they cause the narrowing of the air passages and the secretion of mucus. They can be inhibited by corticosteroid drugs.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Leukotrienes

A class of small molecules produced by cells in response to allergen exposure; they contribute to allergy and asthma symptoms.

Mentioned in: Leukotriene Inhibitors

Mentioned in

References in periodicals archive

Effect of montelukast on exhaled leukotrienes and quality of life in asthmatic patients.

Effectiveness and Quality of Life with Montelukast in Asthma - A double-blind randomized control trial

It was shown that cysteinyl leukotrienes induce the activation of mast cells.

Protective Effects of Montelukast Against Stress-Induced Degeneration of the Urinary Bladder/Stres ile Uyarilmis Mesane Hasarina Karsi Montelukastin Koruyucu Etkileri

When the animals were 12 months old, the equivalent of age 60 in humans, they were treated with zileuton, a drug that inhibits leukotriene formation by blocking the 5-lipoxygenase enzyme.

Researchers Reverse Cognitive Impairments in Mice with Dementia

Prednisolone is an anti-inflammatory drug that reduces prostaglandin and leukotriene synthesis by inhibiting phospholipase-A2, a preoperative, single oral dose of 30mg of prednisolone significantly reduced pain after root canal treatment.9

EFFECTIVENESS OF PRETREATMENT PREDNISOLONE ON POSTENDODONTIC PAIN IN COMPARISON TO PLACEBO

Cysteinyl leukotrienes are lipid mediators inducing proinflammatory signaling through the activation of specific receptors.

Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

Montelukast reduces seizures in pentylenetetrazol-kindled mice

Like zafirlukast, montelukast is a competitive antagonist for the cysteinyl leukotrienes. It binds with high affinity and selectivity to the CysLTl receptor subtype.

Application of nonsteroidal agents

Effects of anti leukotrienes in the treatment of asthma.

Comparative evaluation of moderate dose inhalational corticosteroid (ICS) fluticasone with the combination of low dose fluticasone and montelukast in moderate persistent bronchial asthma

Previous studies have shown that omega-3 fatty acids are associated with lower risks of cardiovascular disease outcomes, but a recent review (Prostaglandins, Leukotrienes & Essential Fatty Acids, online Sept.

Don't overdose on omega-3s

Cysteinyl leukotrienes (cysLTs), specifically LTs [C.sub.4], [D.sub.4], and E4, are generated predominantly by cells of the innate immune system following exposure to allergens, proinflammatory cytokines, and other types of receptor-dependent stimuli.

Cysteinyl leukotriene receptor-1 antagonists as modulators of innate immune cell function