ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.

References in periodicals archive

ABCB1 was mainly expressed by cells in the [CD45.sup.+] subpopulation while ABCC1 was expressed in both subpopulations [29].

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations

Only ADAM17 and ABCC1 were significantly differentially expressed in NR or ONR without stratifying them into CTC+/-.

Gene Expression Signatures in Circulating Tumor Cells Correlate with Response to Therapy in Metastatic Breast Cancer

Although it has been shown that expression of ABCC1 gene is induced by estrogen and progesterone in human trophoblast cells [18], regulatory mechanisms of the expression of PG transporter genes, ABCC1, ABCC9, SLCO4C1, and SLCO5A1 are not well understood.

Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs

Cole, "Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)," The Journal of Biological Chemistry, vol.

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins

ABCBl, ABCC1 and ABCG2 mRNA expression levels were quantified by real-time RT-PCR as described previously (Teng et al.

[beta]-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function

Specifically, the genetic polymorphisms of ABCB1, ABCC1, and ABCG2 in both normal and pancreatic cancerous specimens were analyzed.

ATP-binding cassette genes genotype and expression: a potential association with pancreatic cancer development and chemoresistance?

Leiber, "ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium," Cellular Signalling, vol.

Sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth

And in the recent study the researchers identified common variants at the beginning and end of the ABC1 and ABCC1 genes.

Gene variants behind cigarette smoke metabolism linked to lung cancer risk

It was located on ABCC1, the efflux carrier gene, which codes for a protein serving as a pump that removes MTX from the cell.

Genes tied to methotrexate response