in·di·rect Coombs test

(kūmz), Avoid the incorrect forms Coomb and Coomb's.

a test routinely performed in cross-matching blood or in the investigation of transfusion reaction: test for patient's serum is incubated with a suspension of donor erythrocytes; if specific antibodies are present, they become attached to the antigen in the donor cells; after a washing with saline, Coombs antihuman globulin is added; agglutination at this point indicates that antibodies present in the original test serum had indeed become attached to donor erythrocytes.

Farlex Partner Medical Dictionary © Farlex 2012

Coombs in·di·rect test

(kūmz in'dĭr-ekt' test)

Laboratory test using serum that contains an antibody that may be used for erythrocyte typing; positive (i.e., abnormal) finding in isoimmunization from previous transfusions of incorrect cross-matching.
See: Coombs test
Synonym(s): indirect Coombs test.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.

Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin

Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test

direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.

Gell and Coombs reaction - see under Gell

indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.

Medical Eponyms © Farlex 2012

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References in periodicals archive

These antibodies can cross the placenta and may lead to a positive indirect Coombs test in the mother.

Coombs test, indirect Coombs test in the mother, and anti-E antibody levels were positive and the diagnosis of hyperbilirubinemia caused by minor blood group incompatibility due to anti-E was confirmed.

Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report

Indirect Coombs test was negative about 1 month after surgery.

The presence of severe anaemia with jaundice and hepatosplenomegaly along with positive direct and indirect Coombs test led to the diagnosis of autoimmune hemolytic anaemia in this case which prompted us to use prednisolone in this case.

Pelvic tumour--an unusual cause of hemolysis

The combination of anemia, reticulocytopenia, hydrops fetalis, and a positive indirect Coombs test suggested Kell isoimmunization.

Hydrops fetalis due to Kell alloimmunization: a perinatal approach to a rare case / Kell Alloimmunizasyonuna Bagli Gelisen Hidrops Fetalis Olgusu: Nadir Gorulen bir Olguya Perinatal Yaklasim

The direct Coombs test is positive in autoimmune haemolytic anaemia, and the indirect Coombs test may or may not be positive.

Adult Onset Still's Disease with Autoimmune Haemolytic anaemia: Two rarities in combination

In addition, direct and indirect Coombs tests were positive.

Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review

Other test results (liver and renal function, serum folate and vitamin B12 levels, lactic dehydrogenase levels, C-reactive protein, serum protein electrophoresis, direct and indirect Coombs tests, and antinuclear antibody tests) were within normal limits, as were viral serologic test results (HIV, hepatitis B virus, hepatitis C virus, parvovirus B19).

Pure red blood cell aplasia and isoniazid use

Direct and indirect Coombs tests were found to be negative, indirect bilirubin value: 3.5 mg/dL (normal: <2 mg/dL), LDH: 800 IU/L (normal: <600 IU/L).

An infant with chronic hemolytic anemia

Both direct and indirect Coombs tests (DCT, ICT) and urine hemosiderin were strongpositive.

Severe bone marrow aplasia and Coombs-positive autoimmune hemolytic anemia in microfilariasis--coincidental or causal?/ Mikrofilariaziste agir kemik iligi aplazisi ve Coombs-pozitif otoimmun hemolitik anemi-sebep mi, rastlanti mi?