antiglobulin

[an″tĭ-glob´u-lin]

an antibody directed against gamma globulin.

antiglobulin test (AGT) Coombs' test.

Coombs test

(kūmz),

a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.

Synonym(s): antiglobulin test

Farlex Partner Medical Dictionary © Farlex 2012

an·ti·glob·u·lin test

(an'tē-glob'yū-lin test)

Laboratory assessment to detect red blood cell antibodies in patient serum (indirect) or immunoglobulin bound to the surface of the red blood cell (direct).

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.

Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin

Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test

direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.

Gell and Coombs reaction - see under Gell

indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.

Medical Eponyms © Farlex 2012

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References in periodicals archive

This study compared the indirect antiglobulin test (IAT) tube method with column agglutination technology (CAT).

Validation of column agglutination technology for blood group alloantibody titration

One of the key tests in helping to distinguish classes of hemolytic anemia is the direct antiglobulin test (DAT).

Transfusion therapy for autoimmune hemolytic anemia patients: a laboratory perspective

The direct antiglobulin test: a critical step in the evaluation of hemolysis.

Testing the performance of fully automated blood cell washers in pretransfusion compatibility testing

Column agglutination technology: the antiglobulin test. Transfusion 1993;33(8):639-43.

COMPARISON BETWEEN CONVENTIONAL TUBE TECHNIQUE AND COLUMN AGGLUTINATION TECHNIQUE FOR ANTIBODY SCREENING AND IDENTIFICATION AT MGM BLOOD BANK, NAVI MUMBAI

One 11-year-old boy with chronic disease was finally diagnosed as Evans syndrome, with positive direct antiglobulin test and markers of hemolysis, two years after diagnosis.

Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis

Direct antiglobulin tests are usually positive during a paroxysm and negative at other times and it is complement and temperature dependent [1, 4].

Serological findings in a child with paroxysmal cold haemoglobinuria

Else et al., "The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia," Blood, vol.

Autoimmune cytopenias in chronic lymphocytic leukemia

Direct antiglobulin test was 1(+) for complement (C3d) and IgG.

Rituximab therapy for refractory autoimmune thrombocytopenia in patients with systemic lupus erythematosus / Sistemik Lupus Eritematozus'lu Refrakter Otoimmun Trombositopenili Hastada rituximab Tedavisi

This finding is supported by an elevated total bilirubin (Table 5), a very low haptoglobin level (<0.05 g/L; reference range 0.30-2.70 g/L) and a positive antiglobulin test (Coombs test).

Common variable immunodeficiency (CVID); a case study

Serum samples were tested for reactivity with artesunate solution or urine metabolites by using the indirect antiglobulin test and a drug-dependent-antibody test with the gel card technique (17-19).

Intravenous artesunate for severe malaria in travelers, Europe

ABBREVIATIONS: UAB = University of Alabama at Birmingham Hospital; DAY = direct antiglobulin test.

Organizing the antibody identification process