Coombs test

(kūmz),

a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.

Farlex Partner Medical Dictionary © Farlex 2012

Coombs test

(kūmz test)

A procedure for measuring antibodies, the so-called anti-human globulin test, using either the direct or indirect Coombs tests.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.

Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin

Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test

direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.

Gell and Coombs reaction - see under Gell

indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.

Medical Eponyms © Farlex 2012

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References in periodicals archive

In our case there was thrombocy to penia with positive Coombs test. Steroid such as prednisone is the initial treatment of choice for Evans syndrome.

Evans Syndrome and pregnancy: A case report with literature review

After taking history and performing physical examination, blood tests were run for complete blood count, peripheral smear, reticulocyte count, coombs test, serum bilirubin, mother and baby's blood group.

ABO Incompatibility in Neonates Coming to a Pediatric Tertiary Care Hospital

Important distinguishing features that may assist in diagnosing TTP in this context include the presence of schistocytes on peripheral smear, a negative Coombs test, normal complement levels, and a low level of ADAMTS13 activity.

Thrombotic thrombocytopenic purpura in the presence of connective tissue disease and HIV infection: a diagnostic and therapeutic challenge in a resourceconstrained setting

A positive Coombs test requires cautious interpretation when there are no other features of autoimmune hemolytic anemia.

Idiopathic autoimmune hemolytic anemia presenting as massive splenomegaly in an elderly male which responded to steroid therapy

She was diagnosed with as autoimmune hemolytic anemia (ATHA) based on a high reticulocyte count, positive direct Coombs test, hemoglobinuria, and low haptoglobin level, and received the conventional treatment of prednisone (2 mg/kg in divided doses) and blood transfusions.

Megadose methylprednisolone (MDMP) treatment in a patient with autoimmune hemolytic anemia (AIHA) resistant to conventional corticosteroid administration: a case report / Konvansiyonel Kortikosteroid Uygulamasina Resiztan Otoimmun Hemolitik Anemili Bir Hastanin Megadoz Metilprednizolonla Tedavisi

We detected autoantibodies on the membrane of BM hemopoietic cells by bone marrow mononuclear-cell-(BMMNC-) Coombs test [4-6] or flow cytometric analysis [7].

Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia

Other possible hemolytic anemia or enzyme deficiencies causes were excluded (negative Coombs test, normal glucose-6-phosphate dehydrogenase enzyme level, normal hemoglobin electrophoresis and bone marrow aspiration).

Refractory hemolytic anemia due to severe swirling flow pattern in chronic mitral regurgitation after myxoma surgery/Miksoma cerrahisi sonrasi gelisen kronik mitral yetersizligine bagli siddetli "swirling" e bagli refrakter hemolitik anemi

Blood work revealed low haptoglobin (< 8 mg/dL), LDH was 778 U/L, retic count was 29.3%, total bilirubin was 2.4 mg/dL, direct Coombs test was positive (warm, polyspecific IgG), and so was the indirect Coombs test.

Primary Sjogren's syndrome and autoimmune cytopenias: a relation often overlooked

The patient was negative for hepatitis A, B, and C virus antibodies and antimitochondrial antibodies and had a negative direct Coombs test result.

Reversible hepatotoxicity of mirtazapine in a patient with major depression/Major depresyonlu hastada mirtazapine bagli, geri donusumlu hepatotoksisite

Diagnosis of CAHA is based on a positive direct Coombs test in the presence of cold agglutinins.

Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review

(This would pertain providing the intended recipient has a negative atypical antibody screen and direct Coombs test and a negative transfusion reaction history.)

Is the routine crossmatch obsolete?

The pro-thrombin time was 11.8sec, and indirect and direct Coombs test was negative.

Severe haemolysis and renal failure precipitated by hepatitis E virus in G6PD Deficient patient: A case report