Miltefosine was the most
cytotoxic drug with an IC50 of 72.26 in PBLs and a consistently higher % inhibition through all the four studied concentrations.
The ability of the increased EGFR signaling to protect MCF-7(TamR) cells from the effects of a panel of
cytotoxic drugs was carefully examined, and it was observed that increased levels of EGFR signaling offered cells no significant protection from any of the five drugs studied, and in the case of certain drugs (most clearly with paclitaxel, but also to a lesser extent with other drugs, including etoposide), high EGFR expressing tamoxifen-resistant cells were significantly sensitized to killing with these agents.
We did not advise any systemic chemotherapy with
cytotoxic drugs due to expected high risk of profound toxicity, as the metabolizing potential for
cytotoxic drugs in this patient is unknown.
It also has several promising preclinical projects that see NanoZolid combined with
cytotoxic drugs and with immune-active substances, such as antibodies.
Using antibodies which selectively recognize cancer cells conjugated with appropriate
cytotoxic drugs, ADCs (antibody-drug conjugates) allow highly cytotoxic molecules to be specifically released at the desired site of action, i.e.
RA is treated with painkillers and
cytotoxic drugs to damp down the autoimmune process.
After identification of Aspergillus niger on culture, inquiries revealed no exposure to steroids,
cytotoxic drugs, or irradiation, and workups for malignancy, human immunodeficiency virus infection, tuberculosis, and diabetes were negative.
Health worker preparing
cytotoxic drugs without adequate precautions have been shown to contaminate themselves and their work environment.
He said that Cancer was one of the fatal diseases which treated with
cytotoxic drugs including Cisplating vomiting was one of the major adverse drug reaction of these drugs which has been the major reason of the patient non compliance and ultimately lead to refusal of curative treatment.