Medical

topoisomerase 1 inhibitor drugs

A range of drugs that interfere with DNA replication by inhibiting the action of the topoisomerase enzymes that allow the uncoiling of the double helix-a necessary preliminary to replication. They are used as anticancer drugs and, by local application, to treat warts. Examples are topotecan (Hycamtin) and irinotecan (Campto).

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Mentioned in

cytotoxic drugs
topotecan

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.