Negative mean Positive mean Negative SE Positive SE Cc 27.500 35.292 3.416 3.375 ZOT 29.375 35.318 4.324 3.505 ETBF 33.685 34.167 3.126 3.333 Fn 35.500 33.380 7.045 3.140 P value P value (adj.) Cc 0.124 0.345 ZOT 0.301 0.749 ETBF 0.919 0.319 Fn 0.793 0.768 Cc, Campylobacter concisus; ZOT,
zonula occludens toxin; ETBF, enterotoxigenic Bacteroidesfragilis; Fn, Fusobacterium nucleatum; SE, standard error; adj., adjusted for age and gender.
Regulation of intercellular tight junctions by
zonula occludens toxin and its eukaryotic analogue zonulin.
(10,11) TJs exist in several cerebral vascular endothelial cells, such as
zonula occludens-1, occluding, and the claudin family.
capreolata (AFC) in the dinitrobenzenesulphonic acid (DNBS) model of experimental colitis in mice, correlating its potential anti-inflammatory activity to the expression of some of the mediators involved in the intestinal inflammatory response, such as pro-inflammatory cytokines, like IL-6, (IL)-1[beta], TNF-[alpha], IL-12 and IL-17, the chemokine intercellular adhesion molecule (ICAM)-l, the enzymes inducible nitric oxide synthase (iNOS) and the metalloproteinase (MMP)-9, as well as two markers of epithelial integrity in the mucosa, the mucin MUC-2 and the transmembrane protein
zonula occludens (ZO)-1.
Irsogladine maleate counters the interleukinI b- induced suppression in gap-junctional intercellular communication but does not affect the interleukin-lb-induced
zonula occludens protein- I levels in human gingival epithelial cells.
List of Abbreviations AF: Atrial fibrillation APD: Action potential duration CaMKII: [Ca.sup.2+]/calmodulin-dependent protein kinases II Cx43: Connexin 43 CV: Conduction velocity DAD: Delayed afterdepolarization EAD: Early afterdepolarization ICD: Implantable cardioverter defibrillator NCX: [Na.sup.+]/[Ca.sup.2+] exchanger PLB: Phospholamban ROS: Reactive oxygen species RyR: Ryanodine receptor SERCA: Sarco-/endoplasmic reticulum [Ca.sup.2+]-ATPase SCA: Sudden cardiac arrest SCD: Sudden cardiac death TGF-[beta]: Transforming Growth Factor-[beta] VT: Ventricular tachycardia VF: Ventricular fibrillation ZO-1:
Zonula Occludens-1.
