claudin

(klaw'din),

A membrane protein, juxtaposed strands of which form tight junctions between epithelial cells.
See also: tight junction, zonula occludens.

[L. claudo, to close up, + -in]

Farlex Partner Medical Dictionary © Farlex 2012

claudin

Any of more than 20 small (less than 22 kD) transmembrane proteins which are part of the proteins in the tight junctions in endothelial and epithelial cells, and are critical for forming the paracellular space through which molecules flow between epithelial cells.

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References in periodicals archive

Some of the upregulated genes comprised genes with important functions in the immune response and proliferation, such as claudin 4 (CLDN4), orosomucoid 1 (ORM1), insulin-like growth factor binding protein 2 (IGFBP2), cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1), and growth arrest-specific 1 (GAS1).

Deoxynivalenol- and zearalenone-contaminated feeds alter gene expression profiles in the livers of piglets

TJ contains a complex of proteins spanning the intercellular cleft (occludin and claudin).

Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases

The most important TJ proteins in the intestinal mucosa are ZO-1, occludin, and claudins [7], and the expression of all 3 in the intestine are decreased by infection with ETEC K88 [24, 30].

Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88

Tight junctions have several membrane and cytoplasmic proteins [33] ; some of these such as occludins, claudins, and zona occludins (ZO proteins) have been well studied [34-38].

HER2 Basolateral versus Circumferential IHC Expression Is Dependent on Polarity and Differentiation of Epithelial Cells in Gastric/GE Adenocarcinoma

Claudin heterogeneity and control of lung tight junctions.

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice

Among the enxtensive literature, for example, Fernando Claudin, La crisis del movimiento comunista.

Los estudios sobre la Revolucion Rusa de 1917 en America Latina

Scheiner-Bobis, "Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells," Cellular Signalling, vol.

Androgen Receptor Localizes to Plasma Membrane by Binding to Caveolin-1 in Mouse Sertoli Cells