This included the distinct populations of transitioning
oligodendrocyte and astrocyte progenitor cells, particularly the early pri-OPC progenitors that support the rapid growth of glioblastoma.
Oligoprogenitor cells were induced in the presence of CSF followed by differentiation to an
oligodendrocyte structure.
(33) used RNA sequencing and showed that long-term in vitro treatment with 9-cis and all-trans RA increased the expression of the negative regulators of
oligodendrocyte differentiation such as HES5.
Devanaboyina et al., "Myelin
oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model," Journal of Autoimmunity, vol.
Rasband, "
Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly," The Journal of Neuroscience, vol.
Fossati has developed a unique way to take human skin cells, create iPSC, convert those into
oligodendrocytes and, she hopes, use the
oligodendrocytes as a better model for studying myelination in MS and evaluating potential MS stem cell therapies.
MO3.13, a human
oligodendrocyte cell line, was purchased from Cellutions Biosystems Corporation (Toronto, Ontario, Canada).
The researchers found, however, that chronic stress also made stem cells in the hippocampus mature into another type of glial cell called an
oligodendrocyte, which produces the myelin that sheaths nerve cells.
Rat Microglia and
Oligodendrocyte Primary Cultures.
The topics include purifying and cultivating retinal ganglion cells from rodents, purifying dorsal root ganglion neurons from rats by immunopanning, purifying astrocytes from transgenic rodents by fluorescence-activated cell sorting, myelinating co-cultures of rat retinal ganglion cell re-aggregates and optic nerve
oligodendrocyte precursor cells, and purifying Schwann cells from the neonatal and injured adult mouse peripheral nerve.
"This suggests there is significant
oligodendrocyte death even before anything else degenerates," he explains, "which identifies a new and important player in the progression of this disease."