CD25

a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2; expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, and neuroblastomas.

Farlex Partner Medical Dictionary © Farlex 2012

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.

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References in periodicals archive

Current strategies to deplete Tregs by using monoclonal antibodies to target cell surface proteins such as CD25 and GITR have demonstrated mixed results, perhaps because CD25 and GITR are also expressed in CD4 and CD8 effector T-cells, resulting in the mAbs killing both the Tregs and the effector T-cells.

Eureka Therapeutics' Preclinical Study Data Published, Demonstrating Selective Depletion of Tregs Using Foxp3 Targeting TCR-mimic Antibody

We used the combination of the surface markers CD4, CD25, and CD127 to identify Tregs.

B- and T-Lymphocyte Attenuator Expression on Regulatory T-Cells in Patients with Severe Sepsis

Splenocytes were stained with anti-mouse CD4 mAb and anti-mouse CD25 mAb (7D4) after incubation with the 2.4G2 antibody.

Mesenchymal stem cells prolong the survival of orthotopic liver transplants by regulating the expression of TGF-[beta]1

T cell proliferative response was assessed against bovine collagen II by measuring incorporation of bromodeoxyuridine into deoxyribonucleic acid of proliferating cells and by expression of CD25 on proliferating cells as percentage of CD3+/bromodeoxyuridine+ and CD3+/CD25+ T-cells, respectively.

T cell reactivity to Collagen II as a possible prognostic marker in patients with rheumatoid arthritis

Decidual and peripheral blood CD4 + CD25 + regulatory T cells in early pregnancy subjects and spontaneous abortion cases.

PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension

Her soluble CD25 eventually returned and was elevated at 9420 pg/mL.

Hemophagocytic lymphohistiocytosis

Though Tregs in mice express CD25 constitutively, in humans only those with CD25 show suppressive function.10 Leprosy reactions in contrast showed a decrease in Treg cells which paralleled the increase in Th17 population.11 Moreover, there was downregulation of intracellular TGF-[beta].11,12 Most reports showed a reduction in Treg cells in patients with ENL reactions compared with non-reaction lepromatous leprosy counterparts.11,12

Distribution of CD4+RORg-T Th17 and CD25+ FOXP3+ Treg in leprosy patients with reversal reaction

Regulatory T cells come in many forms with the most well-understood being those that express the markers CD4, CD25, and FOXP3.

HIV vaccine comes closer to reality

Tusk Therapeutics, Cancer Research UK (via its Commercial Partnerships Team) and UCL announced in 2017, an exclusive licensing and collaboration deal to develop and commercialise antibody-based therapeutics against CD25.

Tusk Therapeutics presents data on to its anti-CD25 programme at AACR Annual Meeting 2018

Although different T cell types with regulatory functions have been identified, the most physiologically relevant Treg population is characterized as [CD4.sup.+] T lymphocytes that constitutively express the IL-2 receptor a-chain, CD25, and the transcription factor Foxp3, comprising approximately 10% of the [CD4.sup.+] T cell compartment [5].

Regulatory T Lymphocytes in Periodontitis: A Translational View