in·ter·leu·kin-8

(in'tĕr-lū'kin),

A cytokine derived from endothelial cells, fibroblasts, keratinocytes, macrophages, and monocytes that causes chemotaxis of neutrophils and T-cell lymphocytes.

Synonym(s): anionic neutrophil-activating peptide, monocyte-derived neutrophil chemotactic factor, neutrophil chemotactant factor, neutrophil-activating factor

Farlex Partner Medical Dictionary © Farlex 2012

IL8

A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.

in·ter·leu·kin-8

(in'tĕr-lū'kin)

A cytokine derived from endothelial cells, fibroblasts, keratinocytes, macrophages, and monocytes that causes chemotaxis of neutrophils and T-cell lymphocytes.
Synonym(s): anionic neutrophil-activating peptide, monocyte-derived neutrophil chemotactic factor, neutrophil-activating factor.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

interleukin-8

A CYTOKINE produced by MONOCYTES that is the substance causing CHEMOTAXIS of T cells and NEUTROPHIL polymorph phagocytes.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Prognostic significance of interleukin-8 and CD163-positive cell-infiltration in tumor tissues in patients with oral squamous cell carcinoma.

Effect of the use of snuff on the levels of interleukin-1 beta and interleukin-8 in the gingival crevicular fluid of periodontitis patients.

Interleukin-1 and interleukin-8 in nicotine-and lipopolysaccharide-exposed gingival keratinocyte cultures.

SALIVARY BIOMARKER INTERLEUKIN-8 LEVELS CORRELATED WITH DIFFERENT PARAMETERS OF NASWAR (SMOKE LESS TOBACCO) USAGE

* The report reviews C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Report Published: C-X-C Chemokine Receptor Type 2 - Pipeline Review, H1 2016

Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung.

Anti-interleukin 8 autoantibody:interleukin 8 immune complexes visualized by laser confocal microscopy in injured lung: colocalization with Fc[gamma]RIIa in lung tissue from acute respiratory distress syndrome patients

The report provides comprehensive information on the C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

* The report provides a snapshot of the global therapeutic landscape for C-X-C Chemokine Receptor Type 1 (CDw128a or High Affinity Interleukin-8 Receptor A or IL-8 Receptor Type 1 or CD181 or CXCR1)

C-X-C Chemokine Receptor Type 1 - Pipeline Review, H1 2016

The researchers observed that the double insult to the cells of both rhinovirus and one of the two pollutants resulted in an enhanced release of cytokines, particularly interleukin-8 and the surface expression of intercellular adhesion molecule 1.

Adding insult to infection: pollution exacerbates the common cold. (Science Selections)

When white blood cells encounter lipid A, they make a cascade of proteins -- such as tumor necrosis factor (TNF), interleukin-1, interleukin-6, and interleukin-8 - that stimulate the immune system.

(Anti-) septic strategies; new drugs hold promise for treating life-threatening bacterial infections