in·ter·leu·kin-6

(in'tĕr-lū'kin),

A cytokine derived from macrophages and endothelial cells that increases synthesis and secretion of immunoglobulins by B lymphocytes; also induces acute-phase proteins. In hepatocytes, it induces acute-phase reactants.

Synonym(s): B-cell stimulatory factor 2, interferon-β2

Farlex Partner Medical Dictionary © Farlex 2012

IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.

in·ter·leu·kin-6

(in'tĕr-lū'kin)

A cytokine derived from fibroblasts, macrophages, and tumor cells that increases synthesis and secretion of immunoglobulins by B lymphocytes.
Synonym(s): B-cell stimulatory factor 2.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

interleukin-6

A CYTOKINE produced by HELPER T CELLS, MACROPHAGES, fibroblasts and MAST CELLS that promotes the growth and differentiation of B cells, T cells and blood stem cells and the induction of ACUTE PHASE PROTEINS.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

But Wedell-Neergaard and co-senior study author Helga Ellingsgaard of the University of Copenhagen suspected that interleukin-6 could also play an important role because it regulates energy metabolism, stimulates the breakdown of fats in healthy people, and is released from skeletal muscle during exercise.

How Exercise Reduces Belly Fat in Humans

Interleukin-6 - A key regulator of colorectal cancer development.

Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children

Keywords: Endometrial thickness, Tumour necrosis factor alpha, Interleukin-6, Infertility, Intracytoplasmic sperm injection.

Cytokines and endometrial receptivity after intracytoplasmic sperm injection - A cohort study at Islamabad

Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice.

EFFECT OF SMOKING ON INTERLEUKIN-6 AND CORRELATION BETWEEN IL-6 AND SERUM AMYLOID A-LOW DENSITY LIPOPROTEIN IN SMOKERS

Interleukin-6 and Interleukin-17 gene polymorphisms and celiac disease susceptibility.

Interleukin-6 and Interleukin-17 gene polymorphisms and celiac disease susceptibility

Hirai, "A case of POEMS syndrome with high concentrations of interleukin-6 in pericardial fluid," Journal of Internal Medicine, vol.

Cytokines in Endocrine Dysfunction of Plasma Cell Disorders

The association between the patient categories (i.e., ART naive versus ART experienced) and serum interleukin-6 levels was not affected after adjustment for the gender of the participants, with the regression coefficient for patient category reducing by 0.13% (b = 15.76 versus b= 15.74).

Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging

Chronic periodontitis enhances the risk of coronary heart disease by elevating the serum concentration of CRP (C-reactive protein)18 and IL-6 (Interleukin-6), which decrease in concentration after treatment.

CHRONIC PERIODONTITIS A POSSIBLE THREAT TOWARDS CVD

Supplementation with Cistanche has been shown to increase naive T cells and natural killer (NK) cells while decreasing memory T cells and pro-inflammatory interleukin-6. (43) One of the characteristics of people who live over 100 years is low levels of interleukin-6.

When immune function "falls off a cliff"

Interleukin-6 (IL-6) is confirmed proinflammatory cytokine which plays central role in the inflammatory response following cerebral hypoxia ischemia (Loddick et al.

Creatine Monohydrate Supplemented Diets Affect Serum Inflammatory Cytokine Levels (IL-6 and IL-18) in Female Albino Mice Following Neonatal Hypoxic Ischemic Encephalopathy

KEY WORDS: Autoimmune rheumatic disease Detection Diagnosis and treatment Soluble interleukin-6 receptor.

Clinical effects of soluble interleukin-6 receptor detection on autoimmune rheumatic disease patients

[1] entitled "can tumor necrosis factor-[alpha] and interleukin-6 be used as prognostic markers of infection following ureteroscopic lithotripsy?" in which they report preoperative and postoperative serum interleukin-6 (IL-6) and tumor necrosis factor-[alpha] (TNF-[alpha]) levels in patients with urolithiasis.

A biochemical evaluation on inflammatory markers after ureteroscopic lithotripsy