This approval is based on data from global, randomized Phase III study (TAGS) evaluating trifluridine/tipiracil versus placebo in patients with metastatic
gastric cancer refractory to standard treatments.
Gastric cancer in Europe affects approximately 130,000 people a year, and it is estimated that 40% of those patients will have metastatic disease.
"Type 2 diabetes mellitus was associated with an increased
gastric cancer risk in H.
After the decision of Ege University School of Medicine Ethics Committee (Date: April 27, 2012; No:12-3.1/1), patients diagnosed with
gastric cancer who applied to the General Surgery Clinic of Ege University School of Medicine were included.
Chu investigated the level of CD147 in 223
gastric cancer patients, and confirmed the association of CD147 with
gastric cancer invasion and metastasis, suggesting that CD147 may be an indicator of tumor recurrence and prognosis.8 Hu's study concluded the same conclusion.9 In terms of miR-203, its influence on
gastric cancer was also studied in recent years, many scholars advocated that the expression of miR-203 was significantly lower in
gastric cancer samples than non-cancerous samples, also demonstrating a close correlation between miR-203 and
gastric cancer.10,11 However, few studies have been performed to evaluate the relationship of these biomarkers as well as their influence on the pathological characteristics in patients with
gastric cancer.
In
gastric cancer, lncRNA-GACAT3 and XIST promote cell growth and invasion by negatively regulating miR-497 expression (20,21).
Gastric cancer is often diagnosed at an advanced stage.
Compare to any other country in the world, as a high risk nation of
gastric cancer, Japan has established a relatively better screening system and shown the obvious achievements.[13],[14] In Japan, a
gastric cancer screening program, named photofluorography, was launched in 1960.[15] Together with other traditional screening methods including double-contrast barium X-rays or panendoscopy, it has been wildly adopted throughout the country.[16] However, these traditional methods leave much more to be desired.
In contrast to equivalent survival outcomes of common solid tumors such as colorectal and breast cancer in the Eastern and Western societies, the West has worse out comes of
gastric cancer surgery compared with Japanese trials (5, 13, 14, 16).
CT-based diagnosis of venous invasion in patients with
gastric cancer and its prognostic value.
EPEX may intensify the breakage of the next EpCAM molecules, followed by the phenomenon of a positive feedback leading to breaking more and more numerous molecules of the protein [6].Due to the role of EpCAM in maintaining the cells integrity, the aim of this study was to establish a role of this protein in
gastric cancer. Moreover, the study focused on the possibility of using EpCAM as a potential prognostic marker in
gastric cancer.
surgeon received additional training in
gastric cancer surgery at SNUH, which performs around 1,000 such surgeries per year, the highest number of treatments, and has the highest success rate.