bile acid

Any of the liver-generated steroid acids, such as cholic acid, that commonly occur in the bile in combination with glycine and taurine as sodium salts.

bile acid

Either of several acids—e.g., cholic acid (CA), chenodeoxycholic acid (CDA)—which are formed in the liver and converted by intestinal bacteria into deoxycholic acid (from CA) and lithocholic acid (from CDA), which are known as secondary BAs. BAs are conjugated in the liver to glycine or taurinese conjugates; glycocholic acid and taurocholic acid form sodium and potassium salts in the alkaline bile in the liver. These conjugated bile acids have a central role in the emulsification and absorption of fatty acids.

Specimen
Serum.

Ref range
< 60 µg/mL—as cholylglycine.

Method
RIA.

Mentioned in

References in periodicals archive

These concentrations were approximately 1000-fold higher than the urinary excretion of 3[beta]-sulfated-[[DELTA].sup.5]-cholenoic acids in noncholestatic liver disease patients with healthy primary bile acid synthesis [5.9 (0.2) [micro]mol/L, n = 7], idiopathic cholestatic liver disease patients with increased primary bile acid synthesis [7.8 (2.3) [micro]mol/L, n = 5], and healthy children [0.13 (0.12) [micro]mol/L, n = 6].

Tandem mass spectrometric determination of atypical 3[beta]-hydroxy-[[DELTA].sup.5]-bile acids in patients with 3[beta]-hydroxy-[[DELTA].sup.5]-[C.sub.27]-steroid oxidoreductase deficiency: application to diagnosis and monitoring of bile acid therapeutic response

Jatrorrhizine promoted the conversion of cholesterol to bile acids and the excretion of bile acids by feces

The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis

Roda, "Acidity in bile acid systems," Polyhedron, vol.

The effect of hydroxyl moieties and their oxosubstitution on bile acid association studied in floating monolayers

The patients with ICP were categorized into two groups according to their serum bile acid levels: mild (<40 [micro]mol/L, n=53) and severe ([greater than or equal to]40 [micro]mol/L, n=31).

Can we predict severity of intrahepatic cholestasis of pregnancy using inflammatory markers?/Enflamatuvar belirtecleri kullanarak gebelik kolestazinin ciddiyeti ongorulebilir mi?

Bile acid synthetic defects and liver disease: A comprehensive review.

Novel Mutations in the 3[beta]-hydroxy-∆5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis

Cholesterol and bile acid were extracted according to Carr's method.

Effects of Saponin from Trigonella Foenum-Graecum Seeds on Dyslipidemia

Results from the Phase 2 study in pediatric cholestasis were presented on the effect of odevixibat on reducing serum bile acids, and improving pruritus and sleep measures in a subset of patients with Alagille syndrome, as well as the effect of odevixibat on reducing serum bile acids and improving pruritus in a small subset of patients with biliary atresia.

Albireo Reports Second Quarter 2019 Financial Results

A clinical drug trial will be starting in early 2020 using rifampicin, an antibiotic that is also an effective treatment for itch outside pregnancy and improves removal of bile acids from the bloodstream.

Treatment for liver disorder during pregnancy ineffective, claims study

Under the company's prior Phase 2 INDIGO clinical trial, the blocking bile acid transport from the intestine to the liver with maralixibat resulted in profound and durable reductions in serum bile acids (sBA), clinically meaningful improvements in pruritus and acceleration of growth in some patients with PFIC2.

Mirum Pharmaceuticals treats first PFIC paediatric patient in Phase 3 MARCH-PFIC clinical trial of maralixibat

Elevated colonic concentrations of the primary bile acid chenodeoxycholic acid (CDCA) or the secondary bile acid deoxycholic acid (DCA) are known to induce water secretion, causing diarrhea.

Functional Gastroenterology Bolus

Veterinarians should consider the CA and bile acid limitations of the Avian/ Reptilian Profile Plus reagent rotor when sampling laying hens.

Biochemical Reference Intervals for Backyard Hens