* The report reviews Lysine-Specific Histone Demethylase 1A (Lysine (K)-Specific Demethylase 1 or Flavin-Containing
Amine Oxidase Domain-Containing Protein 2 or EC 1.) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Shevchenko, Thermostable AY- cyclodextrin conjugates of two similar plant
amine oxidases and their properties, Biotechnol.
Welford et al., "Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing
amine oxidase," Journal of Biological Chemistry, vol.
The enzymes used in their work include amino acid-lyases, (48)-(57) aromatic amino acid decarboxylases, (58)-(64) and
amine oxidases. (65)-(72) When they started their work, enzymes were not routinely purified or particularly well characterized.
The
amine oxidase preparation was stable at -18[degrees]C and there was no detectable loss of activity in 6 months at this temperature.
Studying a bovine
amine oxidase, two independent research groups found clues that pyrroloquinoline quinone (PQQ) might be the enzyme's missing sidekick in cows -- and perhaps in humans as well, Klinman says.
The copper-containing
amine oxidases (monoamine oxidase, semicarbazide-sensitive
amine oxidase, histamine deaminase, amine oxygen oxidoreductase) are ubiquitous metalloenzymes as they have several essential functions in the metabolism of primary amines.
Acrolein is the principal cytotoxic metabolite of the anticancer and arthritis drug cyclophosphamide and is the principal and most physiologically active metabolite of allylamine (15), which is metabolized intracellularly to acrolein via semicarbazide sensitive
amine oxidase. The activity of this enzyme is high in artery wall cells (16).
In developing the biosensor, they used the enzymes diamine oxidase, monoamine oxidase and plasma
amine oxidase as the specific biological recognition compounds in a continuous flow system.