In Taiwan, only one drug in this class (
moclobemide) is approved.
[1, 27, 76, 78] In a prospective study carried out in Turkey investigating the efficacy and tolerability of
moclobemide therapy in 21 FM patients, there was no significant improvement in symptoms other than pain and it was concluded that
moclobemide could be used in patients with FM who had severe depression.
Stefanis, "Clinical, endocrine and neurochemical effects of
moclobemide in depressed patients," Acta Psychiatrica Scandinavica, vol.
The reagents used in the enzymatic assay including Ampliflu[TM] Red (10-acetyl-3,7-dihydroxyphenoxazine), peroxidase from horseradish, hMAO-A, hMAO-B, [H.sub.2][O.sub.2], tyramine hydrochloride, selegiline, and
moclobemide were purchased from Sigma-Aldrich (Steinheim, Germany).
In recent years, the MAOI has been represented by
moclobemide, which selectively reversibly inhibits type A MAO and has been attracting attention again due to its side effects.
The patient had been administered different medication regimens for the last 3 years and lamotrigine 100 mg/day and
moclobemide 600 mg/day for the last 1.5 years.
In terms of active principle, amitriptyline (34.7%) and imipramine (13.9%) were the most used among the TCAs, fluoxetine among SSRIs (18.1%) and
moclobemide among the MAOIs (5.1%).