vincristine

[vin-kris´tēn]

a vinca alkaloid used as an antineoplastic agent, primarily as a component of combination chemotherapy regimens for Hodgkin's disease, acute lymphoblastic leukemia, and non-Hodgkin's lymphomas, as well as in the treatment of other neoplastic disorders including Wilms' tumor, neuroblastoma, AIDS-associated Kaposi sarcoma, and rhabdomyosarcoma. Administered intravenously as the sulfate salt.

vincristine

(vĭn-krĭs′tēn′)

An alkaloid, C₄₆H₅₆N₄O₁₀, originally obtained from the Madagascar periwinkle and used in its sulfate form to treat acute leukemia and a variety of other neoplasms.

MOPP

A 4-drug chemotherapy regimen for stage-III Hodgkin lymphoma.

Adverse effects
Sterility, nausea, vomiting, immunosuppression, increased infections, myelosuppression, myelodysplasia, ANLL.

vincristine

Oncovin® AIDS A dimeric vinca alkaloid used to treat KS, thrombocytopenia, leukemias, lymphomas, solid tumors and other CAs which, like vinblastine, interrupts the mitotic spindle, causing lysis of proliferating cells Adverse effects Reversible peripheral neuropathy, constipation. Cf Vinblastine.

vincristine

A vinca alkaloid anticancer drug used to treat LEUKAEMIA. The drug is on the WHO official list. A brand name is Oncovin.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

The effect of increased lipoproteins levels on the disposition of vincristine in rat.

Sub-Chronic Administration of Vincristine Sulfate Induces Renal Damage and Apoptosis in Rats via Induction of Oxidative Stress and Activation of Raf1-MEK1/2-Erk1/2 Signal Transduction/ La Administracion Subcronica de Sulfato de Vincristina Induce Dano Renal y Apoptosis en Ratas por Induccion de Estres Oxidativo y Activacion de la Transduccion de Senales Raf1-MEK1/2-Erk1/2

Five of the 6 patients were retreated with vincristine and all responded to treatment.

Vincristine as an Adjunct to Therapeutic Plasma Exchange for Thrombotic Thrombocytopenic Purpura: A Single-Institution Experience

Cassady, "Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D and cyclophosphamide) and radiation therapy," Cancer, vol.

Single-Centre Experience of Systemic Treatment with Vincristine, Ifosfamide, and Doxorubicin Alternating with Etoposide, Ifosfamide, and Cisplatin in Adult Patients with Ewing Sarcoma

In patients with RMS, chemotherapy regimens considered in recurrent disease include vincristine, doxorubicin, and cyclophosphamide; ifosfamide and etoposide; and vincristine, irinotecan, and temozolomide [32, 33].

Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

A, Schedule of cell cycle synchronization showing the time of each cell cycle phase and the double blockade with serum deprivation and vincristine made to analyze the origin of micronuclei according to BrdU-1 and BrdU-2 assays.

Cell cycle synchronization and BrdU incorporation as a tool to study the possible selective elimination of ErbBI gene in the micronuclei in A549 cells

In order to check the effect of mogoltacin on cytotoxicity of vincristine, it was necessary to find IC50 of vincristine on TCC cells first.

Mogoltacin enhances vicristine cytotoxicity in human transitional cell carcinoma (TCC) cell line

A therapeutic monoclonal antibody approved as first-line treatment for diffuse large B-cell, CD20-positive, non-Hodgkin's lymphoma (NHL), taken in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or with other anthracycline-based chemotherapy regimens.

Rituxan

The regimen, known as the Stanford V, involves a combination of doxorubicin, vinblastine, nitrogen mustard, vincristine, bleomycin, etoposide, and prednisone with differing levels of radiation given for 8 or 12 weeks.

'Stanford V' regimen looks promising for Hodgkin's patients

The committee will also review Ilex/Enzon's liposomal vincristine formulation Marqibo NDA (21-600) for relapsed aggressive non-Hodgkin's lymphoma and Ilex' Clolar (clofarabine) NDA (21-673) for pediatric patients (1-21 years) with refractory or relapsed acute leukemias on Dec 1.

Berlex Bonefos review

Cancer-fighting weed derivatives include vinblastine for Hodgkin's disease and vincristine for childhood leukemia, reports John Richard Stepp, a University of Florida anthropologist, in the Journal of Ethno-Pharmocology.

Weeds as medicines