* VPV regimen:
vinblastine, cisplatin, and etoposide.
Vinblastine has been reported among others to be successful in patients with aggressive disease [5].
Table 1 Inhibition of
vinblastine (VIN) and paclitaxel (PTX) as a single agent and its potentiation by L-canavanine (L-CAV) toward growth of human cancer cells.
The pathways responsible for making many of periwinkle's alkaloids, including
vinblastine, are so elaborate that scientists have worked out few of the specifics.
c) Arjunic acid in Terminalia is a less active cytotoxic agent than
vinblastine.
PUVA and topical nitrogen mustard seem to be most effective for the skin lesions while
vinblastine or etoposide have been used for the systemic manifestations (J.
As palliative treatment, he received 4x10 mg
vinblastine for his residual disease.
Agents used included doxorubicin, cyclophosphamide, pad taxel, bleomycin, cisplatin, and
vinblastine. The mean number of treatments was 4.4, said Dr.
For example, as recently as the 1980s, the plant rosy periwinkle (Catharanthus roseus) gave rise to two important drugs,
vinblastine and vincristine, which are used to treat Hodgkin's disease and childhood leukemia, respectively.
But right now, drug companies must harvest the anticancer substances,
vinblastine and vincristine, from the plant itself.
- US-based Seattle Genetics, Inc.'s (NASDAQ: SGEN) collaborator, Takeda Pharmaceutical Company Ltd., has received approval from the European Commission to extend the marketing authorisation for Adcetris (brentuximab vedotin) to include Adcetris in combination with AVD (Adriamycin,
vinblastine and dacarbazine) in adults patients with previously untreated CD30+ stage IV classical Hodgkin lymphoma.