These corticobasal bodies can be stained with Gallyas, are tau-4R immunoreactive, and are found mostly in the frontal and parietal cortex, in contrast to Pick bodies in Pick disease. A dominant, and in the case of CBD a characteristic, finding are numerous Gallyas- and tau-immunoreactive threads in the neuropil of affected gray matter structures and adjacent white matter.
Pick disease showing granular neurons of the dentate fascia of the hippocampus with tau- immunoreactive cytoplasmic inclusions (a).