The origin and differentiation of the alpha and beta cells in the
pancreatic islets of the rat.
Pancreatic islets tissue-engineered in the current generated by the process not only quickly developed a vascular network after transplant into animal models of type 1 diabetes, the tissues also functioned efficiently as part of the endocrine system -- secreting hormones like insulin and stabilizing glycemic control in the animals.
Rodriguez-Menendez et al., "A double mechanism for the mesenchymal stem cells' positive effect on
pancreatic islets," PLoS One, vol.
Regarding the study of mechanisms, an in vivo study demonstrated that methimazole-induced hypothyroidism promotes immune cell infiltration into
pancreatic islets of female rabbits, which could be inducing pancreatitis and insulitis [79].
In the pancreatic endocrine portion, ghrelin-ip cells were located among the
pancreatic islet cells, and and the distribution of ghrelin-ip cells was observed mostly at the periphery of the islet, a few ghrelin-ip cells were found in the central portion of
pancreatic islets.
Immunohistochemical and morphometric study of the rat
pancreatic islets. J Anat.
Accordingly, we recently demonstrated that HyO
pancreatic islets present a higher [beta]-cell number per islet, indicating that compensatory morphofunction alterations in the HyO pancreas are accompanied by enhanced islet-cell replication, induced by vagal hypertonia, since truncal vagotomy in HyO rats normalized [beta]-cell amount per islet (17).
Also, our previous study on rat model of diabetes has shown that STZ markedly cause reduction in [beta]-cells mass and
pancreatic islets in adult rats (Golalipour et al., 2010).