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cofactor

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cofactor

 [ko´fak-ter]
an element or principle, e.g., a coenzyme, with which another must unite in order to function.
heparin cofactor II a member of the serpin group that inhibits thrombin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

co·fac·tor

(kō'fak'ter, tōr),
1. Synonym(s): coenzyme
2. An atom or molecule essential for the action of a large molecule, for example, heme in hemoglobin, magnesium in chlorophyll. Solo metal ions are regarded as cofactors for proteins, but not as coenzymes.
Farlex Partner Medical Dictionary © Farlex 2012

cofactor

(kō′făk′tər)
n.
1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

co·fac·tor

(kō'fak'tŏr)
1. Synonym(s): coenzyme.
2. An atom or molecule essential for the action of a large molecule; e.g., heme in hemoglobin, magnesium in chlorophyll.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cofactor

a substance that is essential for the catalytic activity of some enzymes, binding to the enzyme only during the reaction. Cofactors can be metallic ions, or nonprotein organic molecules (coenzymes) such as vitamins in the B-COMPLEX.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

co·fac·tor

(kō'fak'tŏr)
An atom or molecule essential for the action of a large molecule.
Medical Dictionary for the Dental Professions © Farlex 2012
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References in periodicals archive
Hereditary heparin cofactor II deficiency and the risk of development of thrombosis.
floresia showed that the crude polysaccharide ([Hf-SP.sub.3]) is able to inhibit the action of thrombin by heparin cofactor II. The clotting time (APTT) is also considerably prolonged in the presence of cofactor VIII and IX deficient plasma.
Hf2s solution (0-100 [micro]g) was mixed with 5 [micro]L of 1.5 [micro]M heparin cofactor II (100 [micro]g [mL.sup.-1]) from Diagnostic Stago, Asnieris, France, in 85 [micro]L of TS/PEG buffer (0.05 M Tris-HCl, 0.15 M NaCl and 1 mg [mL.sup.-1] polyethylene glycol 8000, pH 7.4).
Heparin cofactor II. Purification and properties of a heparin-dependent inhibition of thrombin in human plasma.
occidentalis (Rhodophyceae) has anticoagulant activity by inhibiting thrombin via antithrombin and heparin cofactor II (endogenous blood coagulation regulators) from the presence of two sulfate esters in a single galactose residue.
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