The partitioning of metals among the (1) nuclei and brown bodies; (2) lysosomes and mitochondria; (3) microsomes; and (4) soluble
cytosolic fraction is presented in Table 2.
Overproduction of FeSOD interferes with signal pathways, leading to induction of
cytosolic Cu/ZnSOD during salt stress.
There was no correlation between alcohol dehydrogenase activity and age, whether expressed as activity per mg
cytosolic protein (Figures 1 and 2) or per gram wet weight liver (Figures 3 and 4).
The 65-kDa
cytosolic protein associated with warm temperature acclimation in goldfish, Carassius auratus.
Since TLR4 often signals through HMGB1 to mediate inflammation [18, 19], we also measured
cytosolic levels of HMGB1 in the mice.
Effect of Thapsigargin on
Cytosolic Calcium in Differentiating Neurons and Effect of Calcium Addition on Thapsigargin-Primed Cells.
Orum Therapeutics is a private biotech company developing a new class of therapeutic antibodies targeting
cytosolic proteins for unmet medical needs in cancer and rare diseases.
Accordingly, western blot results did not reveal significant changes in NF-[kappa]B levels after 12 h of PM2.5 stimulation compared with baseline levels, but significantly decreased
cytosolic levels of NF-[kappa]B and increased nuclear levels were observed at 24 and 48 h of PM2.5 stimulation (Figure 4(a)).
By detecting
cytosolic DNA, STING traffics to the lysosome, where it induces membrane permeabilization and subsequent [K.sup.+] efflux that activates NLRP3-associated inflammasomes.
The data generated from the company's pre-clinical proof of concept demonstrated that CPABs can penetrate cancer cells and act on targets within the
cytosolic space to induce a therapeutic effect (induce apoptosis and death of the cancer cells).
The lysine (K) residues K5 and K12 on most newly synthesized
cytosolic histones type H4 are acetylated (Burgess and Zhang 2013).