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cold agglutinin disease

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cold agglutinin disease

Cold agglutinin syndrome Clinical immunology An immune disorder characterized by IgM autoantibodies that optimally agglutinate RBCs at very low temperatures–eg, 4ºC; low titers–< 1:32 of cold agglutinins–CAs are detectable in many normal subjects; polyclonal CAs ↑ after certain infections–eg, mycoplasma, CMV, EBV, trypanosomiasis, and malaria, peak in 2-3 wks and are insignificant if non-hemolytic; CAs may occur in any Pt with acquired hemolytic anemia and a positive direct Coomb's test; certain antibodies have been implicated–eg, anti-I, -i, -Pr, -Gd, Sda. See Autoantibody. Cf 'Room temps. '.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Cold Agglutinin Disease is a very, rare, immune mediated condition, in which components of blood agglutinate in the vessels, causing thrombus formation with subsequent loss of blood supply.
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In addition, Apellis and SFJ have entered into a letter of intent to negotiate and enter into a joint development agreement to support Apellis' clinical development programs for APL-2 for the treatment of patients with cold agglutinin disease and warm antibody hemolytic anemia.
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The author mentioned the treatment methods recommended for cold agglutinin disease, which is a type of autoimmune hemolytic anemia (AIHA).
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Idiotypic/antiidiotypic interactions are suggested to suppress tissue damage caused by autoantibodies in a number of conditions including autoimmune thyroiditis, SLE, pernicious anemia, cold agglutinin disease, myasthenia gravis, and idiopathic thrombocytopenic purpura.
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