cholic acid

[ko´lik, kol´ik]

one of the primary bile acids, usually found conjugated with glycine or taurine; it facilitates fat absorption and cholesterol excretion.

cho·lic ac·id

(kō'lik as'id),

A family of steroids comprising the bile acids (or salts), generally in conjugated form (for example, glycocholic and taurocholic acids). Chemically, cholic acids are cholan-24-oic (cholanic) acids (the terminal C₂₄ of cholane becoming a -COOH group); biologically, cholic acids are derived from cholesterol (a cholestane derivative) and display varying degrees of oxidation (OH groups) and orientation at positions 3, 7, and 12. It is these oxidations and orientations that distinguish the several cholic acid; for example, cholic acid is 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid, and deoxycholic acid is 3α,12α-dihydroxy-5β-cholanic acid. Cholic acid is a naturally occurring detergent in mammals that aids in the digestion of fats.

Synonym(s): cholalic acid, cholanic acid

Farlex Partner Medical Dictionary © Farlex 2012

cholic acid

(kō′lĭk)

An abundant crystalline bile acid, C₂₄H₄₀O₅, derived from cholesterol.

cho·lic ac·id

(kō'lik as'id)

A family of steroids comprising the bile acids (or salts), generally in conjugated form (e.g., glycocholic and taurocholic acids); cholic acids are derived from cholesterol.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cholic acid

a crystalline BILE acid.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Mentioned in

References in periodicals archive

Metal cholates preparation in aqueous solvent: cholic acid was dissolved in aqueous sodium hydroxide solution, then treated with one equivalent of aqueous metal salt solution.

Synthesis and antibacterial activity studies of monosubstituted metal cholates against P. aeruginosa and S. aureus isolated from clinical samples

Unless alternative nondestructive methods of hydrolysis are used, GC-MS cannot be reliably used to monitor changes in the urinary excretion of 3[beta]-sulfated-[[DELTA].sup.5]-cholenoic acids in patients undergoing cholic acid therapy, in whom reductions in the concentrations of atypical bile acids represent one of the main biochemical endpoints for efficacy.

Tandem mass spectrometric determination of atypical 3[beta]-hydroxy-[[DELTA].sup.5]-bile acids in patients with 3[beta]-hydroxy-[[DELTA].sup.5]-[C.sub.27]-steroid oxidoreductase deficiency: application to diagnosis and monitoring of bile acid therapeutic response

Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; G, glycine-conjugated; LCA, lithocholic acid; MCA, muricholic acid; NS, not significant; T, taurine-conjugated species; UDCA, ursodeoxycholic acid.

Persistent organic pollutants modify gut microbiota-host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Cholic acid will be marketed as Cholbam by Asklepion Pharmaceuticals, the FDA said in its statement.

FDA approves cholic acid for rare metabolic conditions

In this research, cholic acid and cheno anti-accumulation agents have been used to prevent the accumulation of dye materials based on indigos.

Performance Drop in Solar Cells Prevented by Nanotechnology

This extract was used for the estimation of fecal sterols and bile acids (cholic acid and deoxycholic acid) by the methods of Zlatkis et al.

Effect of water-soluble gummy fiber, water-insoluble neutral detergent fiber isolated from Syzygium cumini seeds on biliary and fecal bile acids and sterols in rats fed a high cholesterol diet

cholic acid and desoxycholic acid) and cholestanes ([C.sub.27]) (e.g.

Dietary supplements containing prohibited substances: a review (Part 2)

From day 13 of gestation, rats in Group A and Group B were injected intraperitoneally with bile acid (cholic acid (CA), Sigma-Aldrich, USA) for 8 days consecutively.

Effect of bile acid on fetal lung in rat model of intrahepatic cholestasis of pregnancy

The whole series of 11 studied BAs comprises nonsubstituted (CnA), monosubstituted (lithocholic acid, LCA), disubstituted (deoxycholic acid, DCA, and derivatives chenodeoxycholic, ursodeoxycholic, and hyodeoxycholic acids, CDCA, UDCA, and HDCA, resp.), and trisubstituted (cholic acid, CA, and dehydroderivatives, 3DHDCA, DHDCA, 3DHCA, and DHCA) cholanic acids.

The effect of hydroxyl moieties and their oxosubstitution on bile acid association studied in floating monolayers

In the in vivo experiment, SCID mice were fed a diet containing 2% of either PS mixture or cholesterol plus 0.2% cholic acid and implanted with 2 x 10(6) tumour cells per mouse.

In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells

The French pharmaceutical laboratory CTRS confirmed in a statement, published on 18 September, that the European Commission has granted marketing authorisation for Orphacol (cholic acid), an orphan medicinal product for the treatment of two extremely rare and life-threatening liver conditions.

ORPHACOL AUTHORISED