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urokinase

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urokinase

 [u″ro-ki´nās]
u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase
Farlex Partner Medical Dictionary © Farlex 2012

urokinase

(yo͝or′ō-kī′nās, -nāz)
n.
An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Abbokinase

A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

urokinase

A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

urokinase

An enzyme found in human urine that is used as a drug to dissolve blood clots occurring within blood vessels. A PLASMINOGEN activator.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.
Medical Dictionary for the Dental Professions © Farlex 2012
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References in periodicals archive
Takehiko et al., "Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor," The Journal of Laboratory and Clinical Medicine, vol.
Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus
Although Urokinase is a thrombolytic drug of the first generation, it is widely used in China.
China Urokinase Markets, 2013-2017 & 2019-2023: Market Size, Competitive Landscape, Prices, Factors, Prospects
A bolus of 2.000.000 IU of urokinase was given and 20 minutes later effective rhythm was achieved.
USE OF HIGH-DOSE OF UROKINASE DURING CARDIOPULMONARY RESUSCITATION FOR CLINICALLY SUSPECTED MASSIVE PULMONARY EMBOLISM
* The risk of recurrent haemorrhage from intracerebral infusion of urokinase has been estimated by previous authors to range from 7% to 15% of treated patients.
STEREOTACTIC COMPUTED TOMOGRAPHIC-GUIDED ASPIRATION AND THROMBOLYSIS OF INTRACEREBRAL HAEMATOMA
Urokinase plasminogen activator receptor on invasive cancer cells: a prognostic factor in distal gastric adenocarcinoma.
Relevance of the plasminogen activation system in the pathogenesis and progression of gastric cancer
Ko et al., "Soluble urokinase receptor and chronic kidney disease," The New England Journal of Medicine, vol.
Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma
Distler et al., "Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: Possible association with microvascular abnormalities and extent of fibrosis," Clinical Chemistry and Laboratory Medicine, vol.
Integration of Genome-Wide DNA Methylation and Transcription Uncovered Aberrant Methylation-Regulated Genes and Pathways in the Peripheral Blood Mononuclear Cells of Systemic Sclerosis
In our patient, we hypothesized that the injected Urokinase lysed one or more clots on the surface of the hemorrhagic areas demonstrated at the autopsy thus permitting the gas contained into the empyema to penetrate the pulmonary vessels and to cause a GE involving multiple vascular beds.
Uncommon Occurrences of Air Embolism: Description of Cases and Review of the Literature
Locri et al., "The urokinase receptor-derived peptide UPARANT mitigates angiogenesis in a mouse model of laser-induced choroidal neovascularization," Investigative Ophthalmology & Visual Science, vol.
Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System
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