uric

[u´rik]

uric acid the end product of purine metabolism or oxidation in the body. It is present in blood in a concentration of about 5 mg/100 ml and is excreted in the urine in amounts of a little less than 1 g per day. In gout there is an excess of uric acid in the blood, and its salts, the urates, form insoluble stones in the urinary tract, or may crystallize and form deposits (see tophus) in the joints and tissues. The presence of high concentrations of uric acid in the urine is significant in the diagnosis of gout, but is of little significance in urinary disorders.

u·ric ac·id

(yūr'ik as'id),

2,6,8-Trioxypurine; white crystals, poorly soluble, contained in solution in the urine of mammals and in solid form in the urine of birds and reptiles; sometimes solidified in small masses as stones or crystals or in larger concretions as calculi; with sodium and other bases it forms urates; elevated levels associated with gout.

Synonym(s): lithic acid, triketopurine

Farlex Partner Medical Dictionary © Farlex 2012

uric acid

A semisolid compound, C₅H₄N₄O₃, that is a nitrogenous end product of protein and purine metabolism and is the chief nitrogenous component of the urine in birds, terrestrial reptiles, and insects.

uric acid

A small purine metabolite excreted primarily by the kidneys, less by the GI tract; ↑ UA occurs in gout, which primarly affects acral joints, associated with deposition of UA crystals in various tissues; ↑ UA occurs in rapid cell turnover–eg, cancer–leukemia, metastases, myeloma, as well as in alcoholism, dehydration due to diuretics, DM, hyperlipoproteinemia, lead poisoning, renal failure, rarely, idiopathic Ref range Serum, ♂, 3.6-8.3 mg/dL; ♀, 2.2-6.8 mg/dL. See Gout. Cf Synovial fluid analysis.

uric acid

The main end product of PURINE metabolism. Uric acid is derived from ADENINE and GUANINE, two of the purines in DNA and RNA (nucleic acids). An excess of uric acid salts in the body can cause GOUT and kidney stones.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

uric acid

see URATE.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Uric acid

A compound resulting from the body's breakdown of purine. It is normally present in human urine only in small amounts.

Mentioned in: Uric Acid Tests

u·ric ac·id

(yūr'ik as'id)

White crystals, poorly soluble, contained in solution in the urine of mammals.

Medical Dictionary for the Dental Professions © Farlex 2012

Mentioned in

References in periodicals archive

Hyperuricemia is a metabolic consequence originating with different etiologies concerned with either increased production or decreased excretion of uric acid or as a combination of both.

Correlation between hyperuricemia and lipid profile in untreated dyslipidemic patients

The charcoal absorbs uric acid, which will help to reduce the effects of gout on the body.

Natural Gout Remedies for Pain and Swelling

In the present study around 90% patients had calcium oxalate (60%), uric acid (18.18%) or calcium phosphate (10.90%) stones, while other forms of stones were scarce.

SHORT COMMUNICATION - Analysis of chemical composition of urinary calculi from Northern border area of Saudi Arabia

Katherine et al11 showed uric acid levels >3.6 mg/dl are linked with 3-fold higher possibility of developing GDM.

TO MEASURE THE FREQUENCY OF GESTATIONAL DIABETES MELLITUS IN PATIENTS WITH RAISED SERUM URIC ACID LEVEL IN FIRST TRIMESTER OF PREGNANCY

Drugs known as xanthine oxidase inhibitors (XOIs) block the activity of an enzyme involved in purine metabolism, thus reducing uric acid levels.

What to Expect from Your Gout Treatment: Follow your doctor's prescription to lower your uric acid levels and your long-term risk of painful flare-ups

"If gout runs in the family, men in particular should limit their intake of alcohol, fats, and foods such as meat, sardines, bacon, mussels, and yeast that are more likely to increase the uric acid level in the body.

Caught out by gout

Uric acid + H20 Uricase Allantoin + H2O H2O2 + Phenolic chromogens Peroxidase Red coloured compound.

SERUM URIC ACID AND HYPERTENSIVE COMPLICATIONS

Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension.

Topiramate and acidosis, losartan for HT and gout

"Dietary strategies include limiting alcohol of all types, especially beer, limiting red meat and shellfish, and limiting high-fructose corn syrup, which is typically found in soft drinks." Your body produces uric acid when it breaks down purines, substances in these foods--the more purines, the more uric acid.

Gout: A Type of Arthritis That is Linked With Heart Disease: Signs of gout may show up in the big toe, but research suggests a connection with many other areas of the body

It is also unknown that uric acid independently can provide useful information during HF which needs further research.

Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease

'Various latest researches have indicated that high levels of uric acid are also an indicator of metabolic syndrome, which causes cardiovascular disease and stroke.

'High uric acid increases risks for kidney disease'

Solomon, M.D., from Brigham and Women's Hospital in Boston, and colleagues evaluated the association between canakinumab, a monoclonal antibody targeting interleukin-1β; serum uric acid levels; and the incidence of gout attacks.

Quarterly Canakinumab Reduces Risk for Gout Attacks; Doesn't affect serum uric acid levels over time, but targets interleukin-1β