thalassemia minor

thalassemia

 [thal″ah-se´me-ah]

a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia.

α-thalassemia (alpha-thalassemia) that caused by diminished synthesis of alpha chains of hemoglobin. The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis. The heterozygous form may be asymptomatic or marked by mild anemia.

β-thalassemia (beta-thalassemia) that caused by diminished synthesis of beta chains of hemoglobin. The homozygous form is called t. major and the heterozygous form is called t. minor.

thalassemia ma´jor the homozygous form of β-thalassemia, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia; hepatosplenomegaly; skeletal deformation; mongoloid facies; and cardiac enlargement.

thalassemia mi´nor the heterozygous form of β-thalassemia; it is usually asymptomatic, but there may be mild anemia.

sickle cell–thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia.

Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

thal·as·se·mi·a mi·nor

[MIM*141800-142310 passim]

the heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.

Farlex Partner Medical Dictionary © Farlex 2012

thalassemia minor

Thalassemia trait Hematology The carrier state for beta thalassemia–heterozygosity, possession of one thalassemia gene; the person is essentially normal

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr)

The heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and widely variable hematologically, with target cells, mild hypochromic microcytosis, and often slightly reduced hemoglobin level with slightly increased erythrocyte count; types of hemoglobin are variable and depend on the gene involved.
Synonym(s): thalassaemia minor.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Cooley,

Thomas B., U.S. pediatrician, 1871-1945.

Cooley anemia - the syndrome of severe anemia with multiple organ disorders. Synonym(s): thalassemia major

Cooley trait - Synonym(s): thalassemia minor

Medical Eponyms © Farlex 2012

thal·as·se·mi·a mi·nor

(thal'ă-sē'mē-ă mī'nŏr) [MIM*141800142310 passim, MIM*141800, MIM*141800-142310 passim]

Heterozygous state of a thalassemia gene or a hemoglobin Lepore gene; usually asymptomatic and quite variable hematologically.
Synonym(s): thalassaemia minor.

Medical Dictionary for the Dental Professions © Farlex 2012