Secondly, the preclinical program expansion indication of PledOx in cellgiftsinducerad peripheral neuropathy (Chemotherapy Induced Peripheral Neuropathy, CIPN) caused by
taxanes. Third, activities required for PledOx market application within oxaliplatin-induced CIPN.
QoL was assessed at six timepoints: at baseline, after administration of one and four cycles of
taxanes, before administration of FE100C, and after one and four cycles of FE100C.
Methods: We included 30 patients who received at least 6 cycles of
taxane regimen for metastatic mPC in the present study.
It is an orally available tubulin targeting agent that has demonstrated efficacy in preclinical studies against hormone sensitive, castration resistant, as well as
taxane resistant prostate cancer.
The
taxanes and vinca alkaloids target that part of the cytoskeleton known as microtubules.
Unlike standard
taxanes that must be administered intravenously, tesetaxel is a capsule that is taken by mouth.
These drugs include vinca alkaloids, platinum-based drugs such as cisplatin, oxaliplatin and carboplatin, and the
taxanes docetaxel and paclitaxel.
The validity of neuropathy and neuropathic pain measures in patients with cancer receiving
taxanes and platinums.
Although mitosis-inhibiting drugs are used successfully to treat a range of cancers, only about 50 percent of ovarian cancer patients respond to
taxanes and it is not yet possible to identify in advance which patients will benefit.
Neratinib (HKI-272) is a potent, low-molecular-weight, orally administered, irreversible, pan-ErbB (i.e., Erb 1,2, and 4) receptor tyrosine-kinase inhibitor which has been successfully evaluated in Phase I studies involving HER2-positive metastatic breast cancer patients previously treated with trastuzumab, anthracyclines and
taxanes.