The content of free amino acids in the
stratum corneum is increased in senile xerosis.
The introduction of high performance liquid chromatography in combination with electrospray ionization and tandem mass spectroscopic methodology for analysis of
stratum corneum ceramides has led to the identification and quantitation of individual molecular species [19].
Electroporation is the other strategy which relies on utilization of whether short (micro-to milli-second), or high-voltage electrical pulses to generate transient pores in the composition of the
stratum corneum [3].
TEWL through the
stratum corneum and skin appendages under non-sweating conditions is the imperceptible water loss.4 It is a true reflection of
stratum corneum barrier function, when there is no sweat gland activity.
The
stratum corneum is the main skin layer providing protection against friction from outside contact and preventing transepidermal water loss (TEWL).
The decreased level of NMF results in a change of pH in
stratum corneum, which may affect the activity of KLK5, 7 and injure the skin barrier further.[sup][35]
Too little moisture causes the
stratum corneum to shrink and makes the skin appear cracked.1
The anti-inflammatory effect was found in the treatment with both particle sizes BetaNP1000 (1000 nm), and BetaNP100 (100 nm), however, the therapeutic response was much higher with the BetaNP100, due to its high diffusion within the
stratum corneum (Abdel-Mottaleb et al, 2012).
Emollients soften while moisturisers add moisture (Lawton 2009) and work to increase the hydration of the
stratum corneum by occluding the skin's surface so that water is not lost.
Then it was mounted on the Franz-type diffusion cells with the
stratum corneum side facing upward into the donor compartment.