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Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension.

Evaluation of the blood ammonia level as a non-invasive predictor for the presence of esophageal varices and the risk of bleeding

Qu et al., "Pancreatic stellate cells: partners in crime with pancreatic cancer cells," Cancer Research, vol.

Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches

Zheng et al., "Curcumin upregulates Nrf2 nuclear translocation and protects rat hepatic stellate cells against oxidative stress," Molecular Medicine Reports, vol.

PPAR[gamma] Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling

The targets of the drug are primarily associated with the activities of hepatic stellate cells: the downregulation of cell activation [307-310], neutralization of fibrogenic and proliferative cell responses [311-313], promotion of cell apoptosis [314], and promotion of matrix degradation [315, 316].

Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis

Geerts, "History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells," Seminars in Liver Disease, vol.

NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation

Alpha Mangostin Decreased Hepatic Stellate Cells Activation as Shown by the Reduced Expression of [alpha]-SMA.

Alpha Mangostin Inhibits the Proliferation and Activation of Acetaldehyde Induced Hepatic Stellate Cells through TGF-[beta] and ERK 1/2 Pathways

CYGB was discovered as a "stellate cell activation-associated protein" and was expected to be useful as a molecular marker that revealed new aspects of the biological nature of Q-HSCs and the mechanisms underlying their activation.

Discovery of cytoglobin and its roles in physiology and pathology of hepatic stellate cells

Hepatic and pancreatic stellate cells (HSCs and PSCs) are two types of nonparenchymal cells with long cytoplasmic processes giving them a typical stellate-shaped appearance.

Human Glial Fibrillary Acidic Protein Gene Promoter Targets Hepatic and Pancreatic Stellate Cells in Transgenic Bama Mini-Pigs

According to the pathogenetic mechanism of hepatic fibrosis, the inhibition of hepatic fibrosis is mainly achieved through three pathways: inhibition or reduction of the damaging effects of harmful factors on hepatic cells; regulation of the expression of cytokines and related signaling proteins, inhibition of the activation of the immune cells or stellate cells, or promotion of apoptosis; and inhibition of collagen hyperplasia or enhancement of collagen degradation.

PROTECTIVE EFFECTS OF MASSON PINE POLLEN AQUEOUS EXTRACT ON ACTIVATED HUMAN HEPATIC STELLATE CELLS

A pilot study of the effects of D-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C.

Nonalcoholic Fatty Liver Disease in Chronic Hepatitis C

showed that TQ treatment reduced the LPS-induced upregulation of COL1 Al and a-SMA in T-HSC/C1-6 cells, an immortalized rat hepatic stellate cell line (Bai et al.

Anti-fibrotic effect of thymoquinone on hepatic stellate cells

Marinosci et al., "Antifibrogenic effect of IFN-[alpha]2b on hepatic stellate cell activation by human hepatocytes," Journal of Interferon & Cytokine Research, vol.

A Chinese herbal medicine, Jia-Wei-Xiao-Yao-San, prevents dimethylnitrosamine-induced hepatic fibrosis in rats

stellate cell

stel·late cell