Researchers discovered that when this gene is activated by short bursts of exercise, it promotes small growths on neurons known as
dendritic spines -- the site at which synapses form.
In the mammalian cerebral cortex, approximately 80% of excitatory axodendritic synapses are formed on the small protrusions of a neuron's dendrite (
dendritic spines).
Additionally, NV-5138 was also observed to increase the number and function of
dendritic spines indicating changes in synaptic morphology in neurons comprising the portion of the brain known to be involved in the maintenance of mood.
Pre-clinical studies have shown that chronic treatment with Bryostatin-1 rescues young Fragile X mice from the disorder phenotypes, including normalization of most Fragile X abnormalities in: 1) hippocampal brain-derived neurotrophic factor expression; 2) postsynaptic density-95 levels; 3) transformation of immature
dendritic spines to mature synapses; 4) densities of the presynaptic and postsynaptic membranes, and; 5) spatial learning and memory.
The BDNF effects on
dendritic spines of mature hippocampal neurons depend on neuronal activity.
In fact, the adult brain is structurally dynamic [35-37],
dendritic spines dynamically turn over in the adult brain [37, 38], and learning novel tasks are associated with a further increase in spine turnover [38].
Without sufficient sleep, the
dendritic spines that receive signals sent by one brain cell to another were reduced in density and length in a specific region of the hippocampus, restricting the animals' ability to consolidate memories.
Changes within the synapse associated with epilepsy are exerted in
dendritic spines [38].