Quinacrine is rapidly absorbed in the gastrointestinal tract with plasma levels increasing two-to-four hours after administration and reaching a peak in 8-12 hours.
Reduction of cytostatic effects of
quinacrine mustard by caffeine," Biochemical Pharmacology, vol.
Quinacrine can be added to either hydroxychloroquine or chloroquine to achieve improvement in patients who don't respond to a single antimalarial agent.
(2.) Rowley JD: Identification of a translocation with
quinacrine fluorescence in a patient with acute leukemia.
Reactive oxygen species generated by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and
quinacrine. Mol.
Often a combination of antimalarials (for example, hydroxychloroquine 200 mg and
quinacrine 100 mg daily) is used when monotherapy is ineffective.8 However, appropriate time intervals (6 weeks to 3 months) must be given to allow these drugs to work maximally.
(37.) de Magalhaes DR et al.,
Quinacrine sterilization for human immunodeficiency virus-positive women, Fertility and Sterility, 2009, 92(1):108-115.
One group reported inhibition of prion propagation by
quinacrine and chlorpromazine in vitro.
Safety and efficacy of
quinacrine in human prion disease (RION-1 study): a patient preference trial.
Four of the most studied drugs are the analgesic flupirtine, intraventricular pentosan polysulphate, amantadine (a dopaminergic drug with anti-influenza virostatic actions) and the anti-malarial,
quinacrine. However, there is insufficient evidence to introduce any into clinical practice at present (6).
(32.) Bolte J, Demuynck C, Lhomme F, Lhomme J, Barbet J, Roques BP Synthetic models related to DNA intercalating molecules: comparison between
quinacrine and chloroquine in their ring-ring Interaction with adenine and thymine.