The dermal infiltrate included histiocytes in all specimens, neutrophils in 11 (48%), and
plasmacytes in 22 (96%).
The dermal infiltrate included histiocytes in all specimens, neutrophils in 11 (48%), and
plasmacytes in 22 (96%), however,
plasmacytes were conspicuous in only 7 specimens (30%).
Complete blood cell count showed a macrocytic anemia with a hemoglobin concentration of 97 g/L, rouleaux formation, and circulating
plasmacytes. Bone marrow contained 85% dystrophic
plasmacytes.
The so activated B-cells transform into
plasmacytes, commence manufacturing antibodies specific to the allergen peptides in question, multiply, and secrete soluble forms of the specific receptor molecule, in other words, allergen specific IgE antibodies conforming with the original allergen peptides, into the lymph and general circulation.
The cellular phenotype in the small intestine consisted primarily of lymphocytes and
plasmacytes. Other acute markers included mucus extrusion and submucosal edema in the stomach.
The infiltration of numerous IgG4-positive
plasmacytes near acinar and ductal cells and around lymphoid follicles was confirmed in BLEL, which was completely consistent with the previous reports.
[7], tissue sections were scored for inflammatory lesions (infiltrations by mononuclear cells, neutrophils, eosinophils, and
plasmacytes, for fibrin exudation and lymphangiectasis), for tissue destruction (enterocyte loss, ballooning degeneration, edema, and mucosal atrophy), and for tissue repair (hyperplasia, angiogenesis, granulomas, and fibrosis).