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pigmented villonodular synovitis

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pig·men·ted vil·lo·nod·u·lar syn·o·vi·tis

diffuse outgrowths of synovial membrane of a joint, usually the knee, composed of synovial villi and fibrous nodules infiltrated by hemosiderin- and lipid-containing macrophages and multinucleated giant cells; the condition may be inflammatory, although recurrence is likely to follow incomplete removal.
Farlex Partner Medical Dictionary © Farlex 2012

pigmented villonodular synovitis

Orthopedics A lesion of knee–less commonly, ankle, hip, shoulder of young adults Management Excision, re-excision DiffDx Fibrosarcoma, synovial sarcoma, incontinentia pigmenti
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

pig·men·ted vil·lo·nod·u·lar sy·no·vi·tis

(pig-ment'ed vil'ō-nod'yū-lăr sin'ō-vī'tis)
Diffuse outgrowths of synovial membrane of a joint, usually the knee, composed of synovial villi and fibrous nodules infiltrated by hemosiderin- and lipid-containing macrophages and multinucleated giant cells; the condition may be inflammatory, although recurrence is likely to follow incomplete removal.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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References in periodicals archive
The diagnosis and treatment of pigmented villonodular synovitis. J Bone Joint Surg Br 1968;50:290-305.
* The report assesses Pigmented Villonodular Synovitis therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type
Jaffe was the first to describe pigmented villonodular synovitis (PVNS) as a chronic proliferative disease that occurs in the joint, tendon and bursa synovium.1 According to Jaffe, PVNS is characterised by thickened and hyper- plastic synovia organised into villi and nodules, which lead to the deposition of intra-cellular haemosiderin pigments.
Pigmented villonodular synovitis. Orthop Clin North Am 2006;37:23-33.
Long-term follow-up of surgically treated localized pigmented villonodular synovitis of the knee.
Pigmented villonodular synovitis is a benign disease of unknown etiology.
Currently, Cabiralizumab is in a Phase 2 clinical trial in pigmented villonodular synovitis (PVNS) and a Phase 1 clinical trial in oncology indications and is being developed under an exclusive worldwide license and collaboration agreement entered into with Bristol-Myers Squibb (BMS).
One case of pigmented villonodular synovitis with FTT was interpreted as Prompt FTT.
Furthermore, additional differential diagnosis should include clear cell chondrosarcoma and joint centric processes such as pigmented villonodular synovitis and geodes.
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