Urinary organic acid information of the patient Urinary organic Values of the Normal acids patient values Adipic acid 6 mg/g creatinine < 140 mg/g creatinine Succinic acid 148 mg/g creatinine < 350 mg/g creatinine Glutaric acid 6 mg/g creatinine < 60 mg/g creatinine Glycolic acid 4 mg/g creatinine < 130 mg/g creatinine 4-OH
phenylacetic acid 33 mg/g creatinine < 250 mg/g creatinine Metylmalonic acid 4 mg/g creatinine < 50 mg/g creatinine 3-OH butiric acid 324 mg/g creatinine < 50 mg/g creatinine Lactic acid 460 mg/g creatinine < 220 mg/g creatinine Oxalic acid 67 mg/g creatinine < 40 mg/g creatinine Fumaric acid 2330 mg/g creatinine < 100 mg/g creatinine
Acetone, [H.sub.2][O.sub.2] (30%, w/w), and
phenylacetic acid were purchased from Merck, Germany.
They also include oxidation of the
phenylacetic acid precursor to o-hydroxyphenylacetic acid (oxidized derivative).
Substrates ATP GTP Formate (Gly) ATP GTP Acetate (Ala) ATP GTP Glycolate (Ser) ATP GTP Lactate (Thr) ATP GTP Thioglycolate (Cys) ATP GTP 3-Methylthiopropionate (Met) ATP GTP Isobutyrate (Val) ATP GTP Isovalerate (Leu) ATP GTP 2-Methylbutyrate (Ile) ATP GTP 4-Aminobutyrate (Pro) ATP GTP
Phenylacetic acid (Phe) ATP GTP 4-Hydroxyphenylacetic acid (Tyr) ATP GTP Indole-3-acetic acid (Trp) ATP GTP Imidazole-4-acetic acid (His) ATP GTP 5-Aminovalerate (Lys) ATP GTP 4-Guanidinobutyrate (Arg) ATP GTP Malonate (Asp/Asn) ATP GTP Succinate (Glu/Gln)
Krauser et al., "The uraemic toxin
phenylacetic acid impairs macrophage function," Nephrology Dialysis Transplantation, vol.
According to the company, Ravicti, an investigational drug, is a pre-pro-drug of
phenylacetic acid, the active moiety of BUPHENYL, the only branded therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle disorders.
[15] Leuba V., Le Tourneau D and Brown J., Stability of
phenylacetic acid in liquid media.
This followed results of an INCB task force under Project Prism that revealed increased use of
phenylacetic acid and pharmaceutical preparations in methamphetamine production.
Found amid nerve cells that spur reproductive activity in fruit flies, the protein is primarily stimulated by two aromas,
phenylacetic acid and phenylacetaldehyde.
The ongoing issue directly affects cosmetics manufacturers relying on chemicals such as acetone, acetic anhydride and
phenylacetic acid to make a range of commercial cosmetic products, but which can also be diverted to make narcotics and psychotropic drugs.
Other relatively odor-active compounds were fruity, sweet and flowery compounds such as ethyl hexanoate, linalool,
phenylacetic acid, and ethyl 2-methylbutanoate, while malty, buttery or cooked-potato-like impressions originated e.g.
amycolatum by supplementary tests, i.e., tyrosine hydrolysis, N-acetylglucosamine assimilation, and
phenylacetic acid assimilation (2); it was reconfirmed by sequencing the internal fragment of the 16S rRNA gene (3).