Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with
panhypopituitarism and diabetes insipidus.
Notable complications following radiation therapy for JNA reported in the literature include
panhypopituitarism, posterior capsular opacification, temporal lobe necrosis, growth retardation, and radiation keratopathy [5].
The hormonal deficiencies were analyzed at the moment of the diagnosis and in the last check-up, and this analysis found the following proportions: for hypothyroidism, 86.7% versus 92% (p = 0.001); for hypocortisolism, 62% versus 78% (p = 0.001); for hypogonadism, 67% versus 76% (p = 0.001); for hyposomatotropism, 89% versus 94% (p = 0.002); and for
panhypopituitarism, 67.8% versus 78% (p = 0.001) (Table 1).
Paul's
Panhypopituitarism was caused by a birth defect which left him with a piece of his skull missing.
In this report, we discuss an interesting case of an infant who presented with a seizure after birth and was later found to have
panhypopituitarism with an absence of pituitary gland, situs inversus, and left ureterocele with hydronephrosis.
Panhypopituitarism (hyposecretion of 3 or more of pituitary produced hormones) is one of the possible presentations.
Clinical manifestations depend on the direction of the expansion toward adjacent structures and include frontoorbital headache (87%); amaurosis (58%); oculomotor palsies (55%); nasal symptoms (38%) that include anosmia, nasal obstruction, hypoacusis, and nasal discharge [8]; endocrine disorders (3%); and
panhypopituitarism (0.8%) [2].
Rodriguez Senchez, "Congenital
panhypopituitarism as part of the solitary median incisor syndrome," Anales de Pediatria, vol.
He obtained significant tumor debulking, resulting in a
panhypopituitarism including diabetes insipidus for which he was treated with desmopressin in a fixed daily dosage scheme and a strict control of intravenous/enteral fluids.
The neurological symptoms, in lowering order of frequency, are diabetes insipidus, exophthalmos, cerebellar ataxia,
panhypopituitarism, and papilledema which correlate with the various radiological finding [11, 12].
reported on the association between endocrine disorders and valgus SCFE, 2 patients with underdeveloped genitalia and 1 with
panhypopituitarism in a series of 7 patients with valgus patients [4].