Lethal vaccinations such as potassium chloride, sodium thiopental and
pancuronium bromide are injected in the patients suffering from various terminal illness such as neurological conditions, last stage of Alzheimer's, chronic lung problem and heart failures.
Among nondepolarizing agents,
pancuronium, cisatracurium, and atracurium have all been studied in the ARDS population.
A study conducted by Dupuis et al (29) found vecuronium better than
pancuronium for reduction of shivering because vecuronium was not shown to increase myocardial work and was associated with fewer complications.
Vecuronium bromide (Org NC 45) is a monoquaternary analogue of
Pancuronium. This agent was synthesised by Savage in 1979 (Churchill Davidson HC), most potent of all the steroid muscle relaxants studied so far.
These are sodium thiopental, which depresses the central nervous system in 30 seconds, inducing a degree of unconsciousness that makes pain undetectable;
pancuronium bromide, a relaxant which takes 30-45 seconds to induce paralysis and respiratory arrest; and potassium chloride, which stops the heart in around 30 seconds.
Vender, "Postanesthesia care unit recovery times and neuromuscular blocking drugs: a prospective study of orthopedic surgical patients randomized to receive
pancuronium or rocuronium," Anesthesia and Analgesia, vol.
IV
pancuronium was used, 6-hourly for 2 days, then as required when spasms occurred.