Unknown syndrome: microcephaly, hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, low set ears, and
osteosclerosis. J Med Genet 1989;26:786-788.
As stated earlier, the impaired function of cathepsin K results in dysfunction of osteoclasts and consequently reduction in bone resorption and remodeling and increased
osteosclerosis and compromises orthodontic and orthopedic treatments [4].
IBMPFD is characterized by variable expression of slow, progressive muscle weakness, Paget's disease of bone with abnormal bone homeostasis, and frontotemporal dementia with early behavioral or language changes caused by valosin-containing protein gene ( VCP ).[sup][1],[11] However, bone X-ray in the proband and his mother showed no osteolysis,
osteosclerosis or cortical thickening, and no mutations were found in VCP gene.
Alem disso, foi realizada revisao de literatura utilizando os termos "osteosclerose" (
osteosclerosis), "osteonecrose" (osteonecrosis), "aluminio" (aluminium), "criolita" (cryolita), "ocupacional" (occupational) nas bases de dados PubMed, SciELO, e Lilacs e em livros-texto para avaliacao das etapas de beneficiamento do aluminio na industria mineradora.
Finally, a computed tomography (CT) scan confirmed the presence of a cystic tumour with surrounding
osteosclerosis located just below the periosteum (Fig.
Bony trabeculae were assessed as either normal, osteosclerotic, osteopenic, or with mixed
osteosclerosis and osteopenia.
Metabolic disorders, such as hypervitaminosis A, pseudohypoparathyroidism, and renal osteodystrophy, could be excluded based on their radiological appearance of periosteal new bone formation in diaphysis with sparing of the medullary cavity (hypervitaminosis A) and generalized
osteosclerosis (pseudohypoparathyroidism, and renal osteodystrophy) along with laboratory abnormalities (i.e., hypocalcemia and hyperphosphatemia in pseudohypoparathyroidism).
Flourosis results in an osteocondensation by altering bone mass through effects on skeletal mineralization, impaired bone resorption and ion induced decreased bone strength.8 These are all contradictory effects leading to a combination of
osteosclerosis, stress fractures, ligamentous calcification, ossification and a radiculomyelopathy owing to mechanical compressive effects.2,9,10