oligodendroglioma

[ol″ĭ-go-den″dro-gli-o´mah]

a neoplasm derived from and composed of oligodendroglia.

ol·i·go·den·dro·gli·o·ma

(ol'i-gō-den'drō-glī-ō'mă),

A relatively rare, relatively slow-growing glioma derived from oligodendrocytes that occurs most frequently in the cerebrum of adult humans; the neoplasm is grossly homogeneous, fairly well circumscribed, moderately firm, and somewhat gritty in consistency with interstitial calcification sufficiently dense so as to be detected by x-ray imaging of the skull. Microscopically, an oligodendroglioma is characterized by numerous small, round or ovoid, oligodendroglial cells with small, deeply stained nuclei (rarely observed in mitosis), and palely stained, indistinct cytoplasm; the neoplastic cells are rather uniformly distributed in a sparse, fibrillary stroma with scattered calcific bodies and an often prominent arcuate vasculature; chemoresponsiveness is associated with loss of heterozygosity on chromosome 1p and 19q.

[oligo- + G. dendron, tree, + glia, + -oma]

Farlex Partner Medical Dictionary © Farlex 2012

ol·i·go·den·dro·gli·o·ma

(ol'i-gō-den'drō-glī-ō'mă)

A rare, slowly growing glioma derived from oligodendrocytes that occurs most frequently in the cerebrum of adults.

[oligo- + G. dendron, tree, + glia, + -oma]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

oligodendroglioma

A slowly growing tumour of the nervous system derived from neural connective tissue cells, the oligodendroglial cells. The cells of the tumour are small, well-defined ‘halo cells’ with round nuclei and clear CYTOPLASM.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Diffuse glial tumors of the central nervous system are classified by the World Health Organization as astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas according to histological findings (1).

The Applicability of Haarlem Integrated Diagnostic System in Diffuse Glial Tumors and Molecular Methods Affecting Prognosis

Oligodendrogliomas are common intra-axial primary brain tumours, and carry special significance due to several key features, which when present provide better prognosis compared to other intra-axial tumours.

Prognostic value of 1p/19q chromosomal codeletion in patients with oligodendroglioma

Oligodendroglioma: a comparison of two grading systems.

A RARE CASE OF DEBILITATING HEADACHE AND ANAPLASTIC OLIGOASTROCYTOMA OF FRONTAL LOBE

Documenting chromosomal arms 1p and 19q codeletion is currently required to establish the diagnosis of oligodendroglioma. The most frequently used technique is FISH, in which the codeletion status is inferred based on the probes used to cover a short segment of each of the chromosomal arms, 1p and 19q.

Diffuse Gliomas for Nonneuropathologists: The New Integrated Molecular Diagnostics

Both primary tumors (medulloblastoma, ependymoma, glioblastoma, and oligodendroglioma) and secondary tumors (e.g., lymphoma and breast cancer) may spread through the subarachnoid space.

A Case of Diffuse Leptomeningeal Glioneuronal Tumor Misdiagnosed as Chronic Tuberculous Meningitis without Brain Biopsy

GBM-Os resemble GBMs but also contain areas resembling oligodendroglioma, whereas GBM-PNETs are rare tumors with the combined features of high-grade glioma and primitive neuroectodermal tumors.

Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival

Expression of 7SL was found near normal level in oligodendroglioma and oligoastrocytoma, but underexpressed in astrocytoma, primary, and secondary GBMs.

Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles

Some research finds that the DEGs are regulated by transcription factors in glioblastoma [35] and microarray technology has been used to identify the DEGs and their functions in the development of three types of glioma (astrocytoma, glioblastoma, and oligodendroglioma) [36].

The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

The patient's father was submitted to a total thyroidectomy for multinodular goiter at age 23 and died at 60 years old of brain tumor (anaplastic oligodendroglioma).

A Pediatric Case of Cowden Syndrome with Graves' Disease