With these additions, the trial now includes 20 expansion cohorts and four exploratory cohorts and aims to enroll up to 1,732 patients with advanced or
metastatic solid tumors such as renal cell carcinoma and urothelial carcinoma, among others.
The objective of this study was to evaluate, from a Canadian public payer perspective, the cost-effectiveness of 6 cycles of docetaxel plus ADT compared to ADT alone to treat patients with high-volume
metastatic HSPC.
As of data cutoff on March 1, 2018, 21 patients with
metastatic NSCLC who either had no prior therapy or had received up to two prior lines of therapy were enrolled in this Phase 2 cohort.
IHC staining is important for diagnosis and treatment, and IHC markers commonly used for the diagnosis of primary RCC are PAX2, PAX8, RCC marker, CD10, and a combination of vimentin and CK.[9] However, the correct diagnosis of
metastatic RCC remains challenging because the morphology of
metastatic RCC differs from that of primary RCC.
Survival rates for someone with
metastatic breast cancer really depend on the type of breast cancer, said Dr.
"Aggressive local therapy in the setting of
metastatic disease needs to be studied carefully before clinical adoption."
Patients with advanced breast cancer require extensive care and intensive use of medical and other resources, but, until this study, there were no reliable estimates of the number of women actually living with
metastatic disease in the United States, the authors said.
These results provide an initial step toward the improvement of lung cancer therapy that is based on measurement of the expression of genes in the
metastatic lymph nodes.
Treatment for
metastatic disease remains unsatisfactory.
Preoperative lymphoscintigraphy showed a focus of increased activity in the left axilla, which was removed and negative on final pathology for
metastatic melanoma.
The key point in RCC presenting with a sinonasal metastasis is differential diagnosis with primary tumors such as adenocarcinomas, angiofibromas, hemangiopericytomas, melanomas, hemangiomas,
metastatic tumors from the breast and lungs, and, more rarely, systemic diseases such as Wegener's and midline granulomas [48].
[1,6] Current acceptable standards of practice include intraoperative frozen sections of SLN for the detection of
metastatic breast carcinoma.