amplification

[am″plĭ-fĭ-ka´shun]

the process of making larger, such as the increase of an auditory or visual stimulus, as a means of improving its perception.

DNA amplification artificial increase in the number of copies of a particular DNA fragment into millions of copies through replication of the segment into which it has been cloned, a type of nucleic acid amplification.

gene amplification a process by which the number of copies of a gene is increased in certain cells because extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. In humans this process is seen most often in malignant cells.

nucleic acid amplification amplification of a specific nucleic acid sequence, such as to test for presence of a given virus or bacteria in a sample. Types include DNA amplification, ligase chain reaction, and polymerase chain reaction.

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References in periodicals archive

Salvador et al., "Advantages of one step nucleic acid amplification (OSNA) whole node assay in sentinel lymph node (SLN) analysis in breast cancer," SpringerPlus, vol.

Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy

Prevalence of Trichomonas vaginalis and coinfection with Chlamydia trachomatis and Neisseria gonorrhoeae in the United States as determined by the APTIMA Trichomonas vaginalis nucleic acid amplification assay.

Diagnosis of trichomoniasis: comparison of wet mount with nucleic acid amplification assays

Corbett recently settled a 2007 infringement suit brought by Idaho Technologies and the University of Utah Research Foundation regarding eight nucleic acid amplification patents (US Patent Nos.

Corbett files claim against Applied Biosystems

Of these 14 workers, 12 (2 exclusively) transported samples and 11 (2 exclusively) prepared the samples; 9 (1 exclusively) performed antigen testing, 2 (0) performed nucleic acid amplification tests and 4 (0) performed virus isolation.

Laboratory exposure to influenza a H2N2, Germany, 2004-2005

"If large-scale studies with symptomatic women support these data, then sequential collection for both culture and nucleic acid amplification is possible," Dr.

Clean-catch urine samples aren't that much cleaner: one specimen, two tests

CHICAGO -- Investigational assays for detection of Chlamydia trachomatis and Neisseria gonorrhoeae via self-collected vaginal swabs are equivalent in their high accuracy to nucleic acid amplification tests already approved by the Food and Drug Administration for detection of symptomatic and asymptomatic infections in women.

Investigational assays for STDs found accurate: involve self-collected vaginal swabs

Urine specimens that have not been processed for LCx[R] resting can be tested by using another FDA-cleared nucleic acid amplification test.

Recall of LCx[R] Neisseria gonorrhoeae Assay and implications for laboratory testing for N. gonorrhoeae and Chlamydia trachomatis. (Notice to Readers)

The disadvantages of nucleic acid amplification methods are that they are labor intensive and do not have high-throughput capacity.

Performance Characteristics of the Becton Dickinson ProbeTec System for Direct Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Male and Female Urine Specimens in Comparison With the Roche Cobas System

The unique ID NOW isothermal nucleic acid amplification technology provides molecular results in just minutes, allowing clinicians to make effective clinical decisions during a patient visit, added the company.

Abbott unveils the next generation of influenza A & B and Strep A Assays on the ID NOW platform

With the advent of polymerase chain reaction (PCR) and other nucleic acid amplification methods, it became possible to detect many viral and bacterial organisms directly from a patient specimen.

CLIA-waived molecular diagnostic tests are poised to transform clinical Microbiology

6,814,934 ("Instrument for Monitoring Nucleic Acid Amplification").

Fluidigm seeks judgment in response to Applied Biosystems letter