methylation

[meth″ĭ-la´shun]

the addition of methyl groups.

meth·yl·a·tion

(meth-i-lā'shŭn),

Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid, the net effect being to reduce tissue basophilia and abolish metachromasia.

Farlex Partner Medical Dictionary © Farlex 2012

methylation

Chemistry
The addition of a methyl group to a molecule.

Molecular biology
The addition of a methyl group to a cytosine residue on double-stranded DNA, a process which plays a major role in regulating gene expression and preventing restriction endonucleases from cutting DNA at their recognition sites.

Methylated genes are inactive; the pattern of methylation or imprinting is critical in gene expression, and may be passed from one generation to the next. Genes may be demethylated or methylated de novo according to the cell’s function, or during normal development. Phosphorylation is another form of semi-permanent gene control.

meth·yl·a·tion

(meth'i-lā'shŭn)

Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid; the net effect being to reduce tissue basophilia and abolish metachromasia.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

methylation

the addition of a methyl group (-CH₃) to an AMINO ACID in a PROTEIN, as in, for example, POST-TRANSLATIONAL MODIFICATION, or to a NUCLEOTIDE in a NUCLEIC ACID; see MODIFICATION AND RESTRICTION SYSTEM. See also METHYL TRANSFERASE.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

meth·yl·a·tion

(meth'i-lā'shŭn)

Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid.

Medical Dictionary for the Dental Professions © Farlex 2012

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References in periodicals archive

BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.

Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles.

Correlation analyses of CpG island methylation of cluster of differentiation 4 protein with gene expression and T lymphocyte subpopulation traits

Even our cellular energy produced by our mitochondria depends on proper functioning of our methylation cycle.

Clues for Clinical Treatment Plans Through Understanding Methylation

2010), and with global or gene-specific DNA methylation alterations (Herbstman et al.

Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging

The PyroMark[R] Q96 ID Pyrosequencing System (Qiagen) was used to determine DNA methylation. The LPL Pyromark CpG assay (PM00037401) was used, which including 4 CpG sites.

Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations in the Metabolic Syndrome

Intriguing differences with respect to the degree of transcriptome [m.sup.5]C methylation, functional classification, and position bias were reported with this technique [36], and it was recently shown that transcriptome [m.sup.5]C promotes mRNA export through methyltransferase NSUN2 and reader ALYREF [37].

Topological Characterization of Human and Mouse [m.sup.5]C Epitranscriptome Revealed by Bisulfite Sequencing

Chemical shifts in areas of DNA that are responsible for cell death, damage and repair - such as occurs in methylation - are known to contribute to the development of cancer over time.

Higher aspirin consumption in breast cancer patients increases mortality rate: Study

Using this assay, we measured the methylation statuses of 4 separate CpG sites that were -38 (CpG 1), -55 (CpG 2), -58 (CpG 3) and -65 (CpG 4) bp respectively from the first exon of the MMP11 gene (transcript 003, GRch37, hg19).

Epigenetic Status of The Human MMP11 Gene Promoter is Altered in Patellar Tendinopathy

Meanwhile, liver from 42-day-old broilers were also used to extract genomic DNA for methylation analysis.

MOLECULAR CHARACTERIZATION, EXPRESSION PATTERNS AND METHYLATION ANALYSIS OF ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2 (ABCG2) IN BROILERS

CHD has been reportedly linked with Antisense non-coding RNA in the INK4 locus (ANRIL) premotor DNA methylation.4 The differences in DNA methylation in vascular tissues with coronary artery disease may provide insight into the mechanisms underlying the development of atherosclerosis.

DNA methylation: Atherosclerosis leading to congenital heart diseases

The Infinium HumanMethylation450 BeadChip array has been widely used to study DNA methylation in human tissues.[11] To the best of our knowledge, there is no report on DNA methylation in local lesions of patients with NSCL.

Genome-Wide Screening of Aberrant Methylation Loci for Nonsyndromic Cleft Lip