Medical

catechol O-methyltransferase

cat·e·chol O-meth·yl·trans·fer·ase

a transferase that catalyzes the methylation of the hydroxyl group at the 3 position of the aromatic ring of catechols, including the catecholamines norepinephrine and epinephrine (thus, converting to normetanephrine and metanephrine, respectively), the methyl group coming from S-adenosyl-l-methionine. An important step in the catabolism of the catecholamines.
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References in periodicals archive
Research findings have shown that low levels of proline dehydrogenase (PRODH) and catechol O-methyltransferase (COMT) in DGS are responsible for the phenotypic representation of psychotic disorders.
Early-onset psychosis in an adolescent with DiGeorge syndrome: A case report
(2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
Autism spectrum disorders: an intervention approach based on genomic analysis
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
BOCA RATON, FLA.--In an open-label pilot study of 36 marijuana-dependent individuals, 12 weeks of treatment with the catechol O-methyltransferase inhibitor entacapone significantly decreased craving for marijuana in 19 (53%) of the study participants.
Entacapone blunts cravings in marijuana users
Other medications that can be associated with psychosis include monoamine oxidase-[beta] inhibitors, dopamine agonists, and catechol O-methyltransferase inhibitors.
Nonmotor PD symptoms impair quality of life
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase.
6-thioguanine nucleotide--adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: Results from a randomized, controlled, open trial
CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS) Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
Drug update: Parkinson's disease
ropinirole 9-24 $6.21 (Requip) mg/day (5 mg t.i.d.) pramipexole 1.5-4.5 $6.75 (Mirapex) mg/day (1 mg t.i.d.) pergolide 0.5-1.5 $5.64 (Permax) mg/day (0.25 t.i.d.) bromocriptine 15-50 $22.44 (Parlodel) mg/day (15 mg b.i.d.) CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
Drug update: Parkinson's disease
Another catechol O-methyltransferase enzyme inhibitor thought to be safer is expected to reach the market soon.
Delay Levodopa in Young Parkinson's Patients
Plasma circulating catechol estrogens are known to be rapidly metabolized by erythrocytic catechol O-methyltransferase to the corresponding guaiacol estrogens, such as 2-methoxyestrone or 2-methoxyestradiol (7,8).
Detection and measurement of urinary 2-hydroxyestradiol 17-sulfate, a potential placental antioxidant during pregnancy
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