glomerulonephritis
[glo-mer″u-lo-nĕ-fri´tis]a variety of nephritis characterized by inflammation of the capillary loops in the glomeruli of the kidney. It occurs in acute, subacute, and chronic forms and may be secondary to an infection, especially with the hemolytic streptococcus.
Histologic appearance of acute glomerulonephritis. A, Normal glomerulus. B, Glomerulonephritis. The glomerulus appears hypercellular and the capillaries are narrowed or occluded. From Damjanov, 2000.
diffuse glomerulonephritis a severe form of glomerulonephritis with proliferative changes in more than half the glomeruli, frequently with epithelial crescent formation and necrosis; it is often seen in cases of advanced systemic lupus erythematosus.
IgA glomerulonephritis IgA nephropathy.
lobular glomerulonephritis (membranoproliferative glomerulonephritis) a chronic glomerulonephritis characterized by mesangial cell proliferation and irregular thickening of the glomerular capillary wall. There are two subtypes: Type I is marked by subendothelial deposits and activation of the classic complement pathway. Type II is marked by heavy deposits in the glomerular basement membrane and activation of the alternative complement pathway. Both types occur in older children and young adults and follow a slowly progressing course with irregular remissions ultimately resulting in renal failure.
membranous glomerulonephritis a form characterized by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane, with circulating antigen-antibody complexes indicating immune complex disease; it may be secondary to any of numerous other conditions. In some cases it may develop into the nephrotic syndrome. Called also membranous nephropathy.
mesangiocapillary glomerulonephritis membranoproliferative glomerulonephritis.
rapidly progressive glomerulonephritis acute glomerulonephritis marked by a rapid progression to end-stage renal disease and histologically by profuse epithelial proliferation, often with epithelial crescents; principal signs are anuria, proteinuria, hematuria, and anemia. Plasmapheresis or high doses of corticosteroids may lead to recovery of renal function.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
mem·bra·nous glo·mer·u·lo·ne·phri·tis
glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material, and clinically by an insidious onset of the nephrotic syndrome and failure of disappearance of proteinuria; the disease is most commonly idiopathic but may be secondary to malignant tumors, drugs, infections, or systemic lupus erythematosus.
Farlex Partner Medical Dictionary © Farlex 2012
membranous glomerulonephritis
Nephrology A common idiopathic nephropathy usually affecting those > age 40, caused by immune complex deposition in the capillary wall of the glomerular basement membrane; it is the most common cause of nephrotic syndrome Clinical Asymptomatic proteinuria or nephrotic syndrome; possibly, edema, weight gain, hypertension, nocturia, anorexia, GFR is near normal Urinalysis Oval fat bodies, hyaline, granular, fatty casts Risk factors HBV, malaria, malignant solid tumors, NHL, SLE, syphilis, etc, drug or substance exposure–gold, mercury, penicillamine, trimethadione, skin-lightening creams Treatment Glucocorticoids and/or immunsuppressants may be used in some Pts. See Glomerulonephritis.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
mem·bra·nous glo·mer·u·lo·ne·phri·tis
(mem'bră-nŭs glō-mer'yū-lō-nĕ-frī'tis)Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material, and clinically by an insidious onset of the nephrotic syndrome and failure or disappearance of proteinuria; the disease is most commonly idiopathic but may be secondary to malignant tumors, drugs, infections, or systemic lupus erythematosus.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012