mannose binding protein

(1) A protein encoded by MASP1 on chromosome 3q27-q28, and found in the serum and liver, that mediates innate antimicrobial defence by binding to specific cell surface high-mannose oligosaccharides of various bacteria, fungi and possibly also viruses (e.g., HIV), killing them by complement-mediated cell lysis or opsonisation.
(2) Mannan-binding protein (mannan-binding lectin), which is encoded by MBL2.

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References in periodicals archive

Mannose binding protein gene mutation associated with unusual and severe infection in adults.

Circulating levels of mannose binding protein in human immunodeficiency virus infection.

Mannose binding protein gene polymorphism in systemic lupus erythematosus.

Disease associations of mannose-binding lectin & potential of replacement therapy

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